| 青蒿素的提取及蒿甲醚的合成 |
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| 引用本文： | 张梅,;陶蕾,;赵凤舞,;陆烯宏,;辛志君,;周翔,;李雪虎.青蒿素的提取及蒿甲醚的合成[J].中兽医医药杂志,2014(5):35-36. |
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| 作者姓名： | 张梅 ;陶蕾 ;赵凤舞 ;陆烯宏 ;辛志君 ;周翔 ;李雪虎 |
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| 作者单位： | [1]甘肃农业大学,甘肃兰州730070; [2]江苏斯威森生物医药工程研究中心有限公司,江苏张家港215634; [3]中国科学院近代物理研究所,甘肃兰州730000 |
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| 基金项目： | 农业科技成果转化资金项目（2013GB24910682） |
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| 摘 要： | 提取、分离青蒿素并合成其衍生物蒿甲醚。以溶剂法从青蒿中提取青蒿素，采用柱层析法进行纯化。通过还原、醚化反应制得其衍生物蒿甲醚。结果青蒿素收率好，纯度高；蒿甲醚合成收率达76．2％。该方法获得的产品质量稳定，产率高，成本低。
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| 关 键 词： | 青蒿素 蒿甲醚 提取分离 合成 |
Extraction of Arteannuin from Herba Artemisiae Annuae and synthesis of Artemether |
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| Institution: | ZHANG Mei,TAO Lei,ZHAO Feng-wu,LU Xi-hong,XIN Zhi-jun,ZHOU Xiang,LI Xue-hu( 1 .Gansu Agricultural University, Lanzhou Gansu 730070; 2.Jiangsu Swellxin Bio-Pharm. Ply. Ltd., Zhangjiagang Jiangsu 215634; 3.Institute of Modem Physics, Chinese Academy of Sciences, Lanzhou Gansu 730000, China) |
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| Abstract: | Objective： To explore the extraction and separation method of Arteannuin and synthesize Artemether. Methods： Arteannuim was exacted with solvent method from and purified with column chromatography, Artemether was synthesizod from arteannuin by steps of reduction and etherification reaction. Results： Arteannuim was extracted and purified with good yields and high purity.Artemether was obtained with a yield of 76.2%： Conclusion： The product obtained by this is stable in quality with high yield and low cost. |
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| Keywords: | arteannuin artemether extract synthesis |
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