Mammalian SAD kinases are required for neuronal polarization |
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| Authors: | Kishi Masashi Pan Y Albert Crump Justin Gage Sanes Joshua R |
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| Institution: | Department of Anatomy and Neurobiology, Washington University Medical School, St. Louis, MO 63110, USA. |
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| Abstract: | Electrical activity in neurons is generally initiated in dendritic processes then propagated along axons to synapses, where it is passed to other neurons. Major structural features of neurons-their dendrites and axons-are thus related to their fundamental functions: the receipt and transmission of information. The acquisition of these distinct properties by dendrites and axons, called polarization, is a critical step in neuronal differentiation. We show here that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization. These kinases will provide entry points for unraveling signaling mechanisms that polarize neurons. |
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