Regulatory role for GTP-binding proteins in endocytosis |
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| Authors: | L S Mayorga R Diaz P D Stahl |
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| Institution: | Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110. |
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| Abstract: | Guanosine 5'-triphosphate (GTP)-binding proteins have been implicated in the transport of newly synthesized proteins along the secretory pathway of yeast and mammalian cells. Early vesicle fusion events that follow receptor-mediated endocytosis as measured by three in vitro assays were blocked by guanosine 5'-O-(3-thiotriphosphate) and aluminum fluoride. The effect was specific for guanosine nucleotides and depended on the presence of cytosolic factors. Thus, GTP-binding proteins may also have a role in the transport of molecules along the endocytic pathway. |
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