Effects of a dairy product fortified with multiple micronutrients and omega-3 fatty acids on birth weight and gestation duration in pregnant Chilean women |
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| Authors: | Mardones Francisco Urrutia Maria-Teresa Villarroel Luis Rioseco Alonso Castillo Oscar Rozowski Jaime Tapia Jose-Luis Bastias Gabriel Bacallao Jorge Rojas Ivan |
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| Institution: | 1Department of Public Health, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Marcoleta 434, Santiago, Chile. mardones@med.puc.cl |
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| Abstract: | OBJECTIVE: To test the hypothesis that maternal food fortification with omega-3 fatty acids and multiple micronutrients increases birth weight and gestation duration, as primary outcomes. DESIGN: Non-blinded, randomised controlled study. SETTING: Pregnant women received powdered milk during their health check-ups at 19 antenatal clinics and delivered at two maternity hospitals in Santiago, Chile. SUBJECT: Pregnant women were assigned to receive regular powdered milk (n = 477) or a milk product fortified with multiple micronutrients and omega-3 fatty acids (n = 495). RESULTS: Intention-to-treat analysis showed that mean birth weight was higher in the intervention group than in controls (65.4 g difference, 95% confidence interval (CI) 5-126 g; P = 0.03) and the incidence of very preterm birth (0.80 just for mean birth weight and birth length in the on-treatment analysis; birth length in that analysis had a difference of 0.57 cm (95% CI 0.19-0.96 cm; P = 0.003). CONCLUSIONS: The new intervention resulted in increased mean birth weight. Associations with gestation duration and most secondary outcomes need a larger sample size for confirmation. |
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