| 不同基因型禽Ⅰ型副粘病毒致病性及全基因组序列分析 |
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| 引用本文： | 傅光华,刘友生,黄瑜,程龙飞,施少华,陈红梅,万春和,林芳,林建生.不同基因型禽Ⅰ型副粘病毒致病性及全基因组序列分析[J].福建农业学报,2011,26(5):691-696. |
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| 作者姓名： | 傅光华 刘友生 黄瑜 程龙飞 施少华 陈红梅 万春和 林芳 林建生 |
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| 作者单位： | 福建省农业科学院畜牧兽医研究所,福建福州,350012 |
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| 基金项目： | 国家自然科学基金项目，福建省自然科学基金项目，现代农业产业技术体系建设专项资金，福建省农业科学院“双百”行动项目，福建省种业创新专项 |
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| 摘 要： | 为了解当前流行于鸭群的禽Ⅰ型副粘病毒的致病性和分子特征,测定分析了两株病毒对不同动物的致病性、病毒的遗传进化地位及其全基因组序列.结果表明,所分离的两株病毒中,M4毒株与疫苗Ulster株同源性最高,为基因Ⅰ型,基因组全长15186 nt,PX2/03毒株则与近来分离自水禽的FP1/02等高致病分离株的同源性最高,为基...
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| 关 键 词： | 基因型 鸭源 禽Ⅰ型副粘病毒 基因组序列分析 |
Pathogenicity and Genome Sequence Analysis of Different Genotype of Avian Paramyxovirus Type 1 |
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| FU Guang-hua,LIU You-sheng,HUANG Yu,CHENG Long-fei,SHI Shao-hua,CHEN Hong-mei,WAN Chun-he,LIN Fang,LIN Jian-sheng.Pathogenicity and Genome Sequence Analysis of Different Genotype of Avian Paramyxovirus Type 1[J].Fujian Journal of Agricultural Sciences,2011,26(5):691-696. |
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| Authors: | FU Guang-hua LIU You-sheng HUANG Yu CHENG Long-fei SHI Shao-hua CHEN Hong-mei WAN Chun-he LIN Fang LIN Jian-sheng |
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| Institution: | (Institution of Animal Husbandry and Veterinary Medicine of Fujian Academy of Agricultural Sciences, Fuzhou,Fujian 350012,China) |
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| Abstract: | To keep track of the pathogenicity and genomic features of avian paramyxovirus type 1 prevailing in ducks,virulence to different animals and genome sequences of two isolates as well as its genetic diversity and evolution were determined.Phylogenetic analysis showed that M4 shared a high identity with vaccine strain Ulster and belonged to genotype I,while PX2/03 isolate clustered with those virulent waterfowl isolates,such as FP1/02,which were belong to genotype VIII.Genome sequencing results showed that the genome size of M4 is 15186 bp,which is six bp shorter than that of PX2/03,and despite the fact that the two isolates shared a high identity of 92.3% with each other,they distinct significantly in pathogenicity.M4 strain was almost nonpathogenic while PX2/03 was highly pathogenic to chicken and different species of ducks.Additional,animal experiment results indicated that Muscovy duck was more susceptible to PX2/03 isolate than Mule duck or cherry valley duck does despite the similar fatality of these animals after infected with strain PX2/03. |
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| Keywords: | genotype duck origin avian paramyxovirus type 1 genome sequence analysis |
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