Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1 |
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| Authors: | D H Hsu R de Waal Malefyt D F Fiorentino M N Dang P Vieira J de Vries H Spits T R Mosmann K W Moore |
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| Institution: | Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304. |
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| Abstract: | Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system. |
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