| m6A修饰及其生殖调控功能研究进展 |
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| 引用本文： | 郭韶珂,裴杰,王兴东,吴晓云,郭宪.m6A修饰及其生殖调控功能研究进展[J].中国畜牧杂志,2022(1):21-27. |
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| 作者姓名： | 郭韶珂 裴杰 王兴东 吴晓云 郭宪 |
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| 作者单位： | 1.中国农业科学院兰州畜牧与兽药研究所甘肃省牦牛繁育工程重点实验室 |
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| 基金项目： | 财政部和农业农村部-国家现代农业产业技术体系建设专项(CARS-37);中国农业科学院创新工程(25-LZIHPS-01);科技援青合作专项(2020-QY-218,2020-QY-212)。 |
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| 摘 要： | N6-甲基腺苷(N6-methyladenosine,m6A)修饰是指mRNA中腺苷酸(A)的第六位氮原子处发生甲基化,m6A修饰是生物mRNA中最广泛存在的内部修饰.m6A修饰通过调节RNA代谢、稳定性、翻译、降解以及选择性剪接来发挥生物学功能,在细胞分化、生物节律、生殖生理、肿瘤发生等方面起到调控作用.本文综述了目...
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| 关 键 词： | RNA甲基化 m6A修饰 精子发生 卵母细胞成熟 |
Research Progress on m~6A Methylation and Its Functions in Reproductive Biology |
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| GUO Shaoke,PEI Jie,WANG Xingdong,WU Xiaoyun,GUO Xian.Research Progress on m~6A Methylation and Its Functions in Reproductive Biology[J].Chinese Journal of Animal Science,2022(1):21-27. |
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| Authors: | GUO Shaoke PEI Jie WANG Xingdong WU Xiaoyun GUO Xian |
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| Institution: | ,Key Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences |
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| Abstract: | N6-methyladenosine(m~6A) refers to a methylation at the sixth nitrogen atom of adenosine(A) in messenger RNAs(mRNAs). The m~6A modification is the most prevalent internal modification in mRNA of all higher eukaryotes. The m~6A modification plays a biological role by regulating RNA metabolism, stability, translation, degradation and selective splicing,and plays a regulatory role in cell differentiation, biological rhythm, reproductive physiology and tumorigenesis. In this paper,we reviewed the current understanding of m~6A methylation, and described the functions of writer, eraser and reader. Besides,the research progress on m~6A methylation in regulating animal reproduction were also be summarized. The aim of this review is to provide technical material and theoretical reference for the research and application regarding with the m~6A methylation in reproductive physiology of domestic animals. |
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| Keywords: | RNA methylation m~6A Spermatogenesis Oocyte maturation |
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