| 复方丹参注射液对急性水肿型胰腺炎患者可溶性粘附分子水平的影响 |
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| 引用本文： | 张美兰,廖文焱.复方丹参注射液对急性水肿型胰腺炎患者可溶性粘附分子水平的影响[J].湛江医学院学报,2006,24(6):576-578. |
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| 作者姓名： | 张美兰 廖文焱 |
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| 作者单位： | 广东省湛江市第二中医院,广东湛江,524013;广东省湛江市第二中医院,广东湛江,524013 |
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| 摘 要： | 目的:研究复方丹参注射液对急性水肿型胰腺炎患者外周血粘附分子水平的影响,探讨复方丹参注射液治疗急性胰腺炎的机制。方法:采用复方丹参注射液结合西药治疗32例急性水肿型胰腺炎患者(治疗组),取常规西药治疗的35例急性水肿型胰腺炎患者(治疗对照组)作为对比观察,并于治疗前后检测患者血液中粘附分子P-选择素(P-sel)和细胞间粘附分子-1(ICAM-1)水平。结果:治疗组的腹痛缓解时间、尿淀粉酶恢复时间和平均住院时间均短于治疗对照组(P<0.05或0.01),临床疗效也优于治疗对照组(H c=5.7902,P<0.05)。治疗前治疗组和治疗对照组的P-sel、ICAM-1比较差异无显著性(P>0.05),治疗后治疗组的P-sel下降较明显,与治疗对照组比较差异有非常显著性(P<0.01),两组治疗后ICAM-1水平差异未见显著性(P>0.05)。结论:复方丹参注射液结合西药治疗对急性胰腺炎有显著疗效,可能与复方丹参注射液能调节免疫细胞粘附分子表达,抑制炎症细胞聚集,进而抑制炎症反应有关。
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| 关 键 词： | 急性胰腺炎 复方丹参注射液 P-选择素 细胞间粘附分子-1 |
| 文章编号： | 1005-4057(2006)06-0576-03 |
| 收稿时间： | 02 15 2006 12:00AM |
| 修稿时间： | 11 21 2006 12:00AM |
Effect of Danshen injection on soluble adhesion molecules in acute edematous pancreatitis |
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| ZHANG Mei-lan,LIAO Wen-yan.Effect of Danshen injection on soluble adhesion molecules in acute edematous pancreatitis[J].Journal of Guangdong Medical College,2006,24(6):576-578. |
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| Authors: | ZHANG Mei-lan LIAO Wen-yan |
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| Institution: | Second Hospital of Traditional Chinese Medicine of Zhanjiang, Zhanjiang 524013, China |
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| Abstract: | Objective: To observe the effect of Danshen injection on soluble adhesion molecules in patients with acute edematous pancreatitis(AEP) and to investigate its action mechanism.Methods: Thirty-two AEP patients(treatment group) were treated with Danshen injection plus Western medicine,while 35 AEP ones(control group) only received Western medicine.Serum levels of P-selectin and intercellular adhesion molecule-1(ICAM-1) in both groups were determined before and after therapy.Results: The effective rate in treatment group was superior to that in control group(P<0.05).Compared with control group,P-selectin content reduced significantly after therapy(P<0.01),but ICAM-1 concentration remained unchangeable(P>0.05).Conclusion: Combined use of Danshen injection and Western medicine is effective in the treatment of AEP.Danshen injection may regulate the expression of some adhesion molecules and then inhibit the inflammatory response in AEP. |
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| Keywords: | acute pancreatitis Danshen injection P-selectin ICAM-1 |
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