A sub-population of circulating porcine gammadelta T cells can act as professional antigen presenting cells |
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| Authors: | Takamatsu H-H Denyer M S Wileman T E |
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| Institution: | Institute for Animal Health, Pirbright Laboratory, Woking, Surrey GU24 0NF, UK. haru.takamatsu@bbsrc.ac.uk |
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| Abstract: | A sub-population of circulating porcine gammadelta T cells express cell surface antigens associated with antigen presenting cells (APCs), and are able to take up soluble antigen very effectively. Functional antigen presentation by gammadelta T cells to memory helper T cells was studied by inbred pig lymphocytes immunised with ovalbumin (OVA). After removing all conventional APCs from the peripheral blood of immunised pigs, the remaining lymphocytes still proliferated when stimulated with OVA. When gammadelta T cells were further depleted, OVA specific proliferation was abolished, but reconstitution with gammadelta T cells restored proliferation. The proliferation was blocked by monoclonal antibodies (mAb) against MHC class II or CD4, and by pre-treatment of gammadelta T cells with chloroquine. These results indicate that a sub-population of circulating porcine gammadelta T cells act as APCs and present antigen via MHC class II. |
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