|
|||||
|
|
Effect of lidocaine on the minimum alveolar concentration of sevoflurane in dogs |
|
| Authors: | Lídia M Matsubara MV MSc Valéria N L S Oliva† MV PhD Daniela T Gabas MV MSc Guillermo C V Oliveira MV & Maria L Cassetari‡ MSc |
| Institution: | Department of Anesthesiology, Faculdade de Medicina, Botucatu, São Paulo, Brazil;Department of Clinics, Surgery and Animal Reproduction, Faculdade de Odontologia, Curso de Medicina Veterinária, Botucatu, São Paulo, Brazil;Department of Public Health, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil |
| Abstract: | Objective To investigate the effects of a low-dose constant rate infusion (LCRI; 50 μg kg Study design Prospective, randomized experimental design. Animals Eight healthy adult spayed female dogs, weighing 16.0 ± 2.1 kg. Methods Each dog was anesthetized with sevoflurane in oxygen and mechanically ventilated, on three separate occasions 7 days apart. Following a 40-minute equilibration period, a 0.1-mL kg Results The MAC of Sevo was 2.30 ± 0.19%. The LCRI reduced MAC by 15% to 1.95 ± 0.23% and HCRI by 37% to 1.45 ± 0.21%. Diastolic and mean pressure increased with HCRI. Lidocaine plasma concentration was 0.84 ± 0.18 for LCRI and 1.89 ± 0.37 μg mL Conclusion and clinical relevance Lidocaine infusions dose dependently decreased the MAC of Sevo, did not induce clinically significant changes in HR or arterial blood pressure, but vomiting was common during recovery in HCRI. |
| Keywords: | blood pressure constant rate infusion dog lidocaine minimum alveolar concentration sevoflurane |
| 本文献已被 ScienceDirect 等数据库收录！ | |