Composition and biological activity of essential oil of Achillea ligustica All. (Asteraceae) naturalized in central Italy: Ideal candidate for anti-cariogenic formulations |
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| Authors: | Filippo Maggi Massimo Bramucci Cinzia Cecchini Maria M Coman Alberto Cresci Gloria Cristalli Giulio Lupidi Fabrizio Papa Luana Quassinti Gianni Sagratini Sauro Vittori |
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| Institution: | 1. University of Camerino, Faculty of Pharmacy, Department of Environmental Sciences, Section of Botany and Ecology, I-62032, Camerino, Italy;2. University of Camerino, Faculty of Pharmacy, Department of Molecular, Cellular and Animal Biology, I-62032, Camerino, Italy;3. University of Camerino, Faculty of Sciences and Technology, Department of Comparative Morphology and Biochemistry, I-62032, Camerino, Italy;4. University of Camerino, Faculty of Pharmacy, Department of Chemical Sciences, via S. Agostino, I-62032, Camerino, Italy |
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| Abstract: | Essential oil from flowers (FL) and vegetative parts (VP) of Achillea ligustica (Asteraceae), naturalized after cultivation in central Italy, was investigated by GC–FID and GC–MS. The most abundant components were linalool, viridiflorol, β-pinene, 1,8-cineole and terpinen-4-ol. The antioxidant assays (DPPH and ABTS radical scavenging assays, and β-carotene bleaching test) demonstrated a moderate activity of essential oils. The antimicrobial activity was evaluated by the broth micro-dilution method on 6 microbial strains and showed to be quite strong against the cariogenic Gram-positive Streptococcus mutans, suggesting that this essential oil could be a valid candidate for anti-cariogenic formulations. Moderate cytotoxic activity was observed in assays on four tumour cell lines by MTT assay. |
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| Keywords: | Achillea ligustica All Asteraceae Essential oil Antioxidant activity Anticariogenic activity Antiproliferative activity |
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