| 异丙酚对失血性休克大鼠小肠黏膜屏障功能的影响 |
| |
| 引用本文： | 莫坚,刘欣,薛晓英,莫桂熙,刘亦君.异丙酚对失血性休克大鼠小肠黏膜屏障功能的影响[J].湛江医学院学报,2014(4):446-447. |
| |
| 作者姓名： | 莫坚 刘欣 薛晓英 莫桂熙 刘亦君 |
| |
| 作者单位： | 广东医学院附属医院麻醉科,广东湛江524001 |
| |
| 摘 要： | 目的观察异丙酚对失血性休克大鼠小肠黏膜屏障功能的影响。方法 36只雄性SD大鼠随机分为对照组和异丙酚组,制作失血性休克模型,经股静脉回输等量林格氏液,异丙酚组加用异丙酚5 mg/kg。18 h后处死大鼠,鲎试＋验测定血浆内毒素含量,免疫组化法检测小肠黏膜固有层IgA细胞,TUNEL法检测小肠黏膜细胞凋亡。结果与对照组＋比较,异丙酚组血浆内毒素含量明显减少,小肠黏膜上皮细胞凋亡指数明显降低,而小肠黏膜固有层IgA细胞数显著升高,差异均有统计学意义（P〈0.01）。结论异丙酚可保护失血性休克对大鼠小肠道黏膜屏障功能的损伤,减轻内毒素血症。
|
| 关 键 词： | 异丙酚 休克 黏膜屏障 内毒素 |
Effect of propofol on mucosal barrier function of small intestine in rats with hemorrhagic shock |
| |
| MO Jian,LIU Xin,XUE Xiao-ying,MO Gui-xi,LIU Yi-jun.Effect of propofol on mucosal barrier function of small intestine in rats with hemorrhagic shock[J].Journal of Guangdong Medical College,2014(4):446-447. |
| |
| Authors: | MO Jian LIU Xin XUE Xiao-ying MO Gui-xi LIU Yi-jun |
| |
| Institution: | (Department of Anesthesiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China) |
| |
| Abstract: | Objective To study the effect of propofol on mucosal barrier function of small intestine in rats with hemorrhagic shock. Methods Thirty-six male rats were randomly divided into control and propofol groups. After successful establishment of hemorrhagic shock models, the same amount of lactate Ringer＇s solution was transfused via the femoral vein, while propofol（5 mg/kg） was added in propofol group. All rats were sacrificed after 18 hours, and plasma endotoxin level, ＋IgA cells of the lamina propria, and apoptosis of the intestinal mucosa were determined by limulus test, immunohistochemistry, and TUNEL method, respectively. Results Compared with the control group, plasma endotoxin level ＋and apoptotic index decreased, while IgA cells increased in the propofol group（P〈0.01）. Conclusion Propofol can protect the mucosal barrier function of small intestine against hemorrhagic shock and alleviate the endoxemia. |
| |
| Keywords: | propofol shock mucosal barrier endotoxin |
| 本文献已被 维普 等数据库收录！ |
|
