Prostanoids-induced dispersion in the melanophores of a carp Labeo rohita (Ham.) |
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| Authors: | M Ovais Fraz Ahmed Md Mubashshir Safia Sumoona |
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| Institution: | 1. Department of Biosciences, Barkatullah University, Bhopal, 462026, MP, India
2. 7—Kausar Bungalows, Opp. Archbishop’s House, Saifia College Road, Koh-e-Fiza, Bhopal, MP, India
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| Abstract: | Effects of three prostaglandins (i.e., prostanoids) and one of its precursors, arachidonic acid, were examined on the melanophores of the fish Labeo rohita (Ham.). PGE1, PGE2, PGF2α and arachidonic acid elicit a concentration-related dispersion in the fish melanophores. In vitro analysis of melanophores was performed through incubation of the isolated fish scales in different agonists and antagonists solutions. Dispersal effect of prostanoids may be mediated directly through the typical receptors or indirectly through release of neurotransmitter substance(s) from the melanophore nerve endings. Denervation of fish melanophores rendered them insensitive to prostanoid (PGF2α). Propranolol and verapamil completely inhibited the dispersal effects of PGF2α; theophylline and indomethacine blocked the effects of higher concentrations of PGF2α. During dispersing influence of PGF2α, a free flux of Ca2+ ions was required and the indirectly released substance(s) from melanophore nerve endings would be the catecholamines of adrenergic and purinergic in nature. |
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