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Anesthetic Potency of Desflurane in the Horse: Determination of the Minimum Alveolar Concentration |
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| Authors: | FJ TENDILLO DVM PhD Diplomate ECVA A MASCÍAS DVM M SANTOS DVM J LÓPEZ-SANROMÁN DVM PhD R De ROSSI DVM F SAN ROMÁN DVM PhD LA GÓMEZ de SEGURA DVM PhD |
| Institution: | Facultad de Veterinaria, Departamento de Patología Animal II, Universidad Complutense de Madrid, Spain. |
| Abstract: | Objective — To determine the minimum alveolar concentration (MAC) of desflurane (DES) in the horse. Study Design — Prospective study. Animals — Six healthy adult horses (three males and three females) weighing 370 ±16 kg and aged 9 ±2 years old. Methods — Anesthesia was induced with DES vaporized in oxygen via a face mask connected to a large-animal, semiclosed anesthetic circle system. The horses were endotracheally intubated and positioned in right lateral recumbency. Inspired and end-tidal DES were monitored using a calibrated Ohmeda RGM 5250 multigas analyzer (Ohmeda-BOC, Spain). The MAC of desflurane that prevented gross purposeful movement in response to 60 seconds of noxious electrical stimulation of oral mucous membranes was determined. Results — The time from the start of DES administration to lateral recumbency was 6.1 ±0.9 min. The MAC of DES in these horses was 7.6 ±0.4%. Time required for the animal to regain sternal recumbency after 98 ±4 minutes of anesthesia was 6.6 ±0.5 minutes and the time to standing was 14.3 ±2.7 minutes. Conclusions — The MAC of desflurane in these horses was 7.6 ±0.4%. DES provided a rapid induction to, and recovery from, anesthesia. Clinical Relevance — Desflurane offers the potential for more precise control during anesthesia, and may allow a faster and uneventful recovery. It is important to know the MAC of an inhalant to use it clinically. |
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