Investigation of Mycobacterium bovis and Metastrongylus sp. co-infection and its relationship to tuberculosis lesions’ occurrence in wild boars |
| |
| Institution: | 1. Centro de Pesquisa em Saúde Animal, Instituto de Pesquisas Veterinárias Desidério Finamor, Departamento de Diagnóstico e Pesquisa Agropecuária, Secretaria da Agricultura, Pecuária e Desenvolvimento Rural, Estrada Do Conde, 6000 - Sans Souci, 92990-000, Eldorado do Sul, Rio Grande do Sul, Brazil;2. Programa de Pós-Graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9090 - Agronomia, 91540-000, Porto Alegre, Rio Grande do Sul, Brazil;3. Feevale, Universidade Feevale, Av. Edgar Hoffmeister, 600 - Zona Industrial Norte, Campo Bom, Rio Grande do Sul, Brazil;1. Equine Research Institute, Japan Racing Association, 1400-4 Shiba, Shimotsuke, Tochigi, 329-0412, Japan;2. Racehorse Clinic, Tokyo Racecourse, Japan Racing Association, 1-1 Hiyoshi-cho, Fuchu, Tokyo, 183-0024, Japan;1. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran;1. Doctorate Student in the Northeast Network in Biotechnology, State University of Ceará, Fortaleza, Ceará, Brazil;2. Embrapa Goats and Sheep, Sobral, Ceará, Brazil;3. Scholarship for Regional Scientific Development of the National Council for Scientific and Technological Development (DCR-CNPq/FUNCAP), Level C, Brasilia, Distrito Federal, Brazil;4. Embrapa Pigs and Poultry, Concórdia, Santa Catarina, Brazil;5. Doctor in Veterinary Sciences, State University of Ceará, Fortaleza, Ceará, Brazil;6. Doctorate Student in Animal Science, Federal University of Piauí, Teresina, Piauí, Brazil;7. Master Degree Student Medical Microbiology, Federal University of Ceará, Fortaleza, Brazil;8. Undergraduate Student in Zootechnics, State University of Acaraú Valley, Sobral, Ceará, Brazil;9. Undergraduate Student in Biological Sciences, State University of Acaraú Valley, Sobral, Ceará, Brazil;10. State University of Ceará, Fortaleza, Ceará, Brazil;1. S.C. Sicurezza e Qualità degli Alimenti, Istituto Zooprofilattico Sperimentale Piemonte, Liguria e Valle d’Aosta, Turin, Italy;2. Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, Italy;3. S.C. Diagnostica Generale, Istituto Zooprofilattico Sperimentale Piemonte, Liguria e Valle d’Aosta, Turin, Italy;4. Laboratorio di Microbiologia e Virologia, Azienda Ospedaliero-Universitaria, Città della Salute e della Scienza di Torino, Turin, Italy;5. Dipartimento di Ispezione degli Alimenti, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici (NA), Italy;6. S.C. Epidemiologia ed Analisi del Rischio, Istituto Zooprofilattico Sperimentale Piemonte, Liguria e Valle d’Aosta, Turin, Italy;1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;3. Department of Medical Parasitology and Mycology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran;4. School of Biology, College of Science, University of Tehran, Tehran, Iran;1. Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;2. Instituto Federal de Minas Gerais, Bambuí, Minas Gerais, Brazil;3. Prefeitura Municipal de Contagem, Contagem, Minas Gerais, Brazil |
| |
| Abstract: | Animal tuberculosis (aTB) is a zoonotic disease characterized by granulomatous lesions on affected tissues, occurring as a consequence of immunological response to infection. Mycobacterium bovis, the main causative agent of aTB, was investigated in Brazilian wild boars with 37.7 % (29/77) positivity. Among these animals, most had no macroscopic tuberculosis-like lesions (89.6 %; 26/29). The existence of co-infections, which may alter an individual's immune response to an immunological challenge, could influence the formation of tuberculosis lesions. Therefore, we investigated Metastrongylus sp. and aTB co-infection to seek an explanation for the absence of macroscopic lesions in aTB. Of the tested animals, 77.9 % (60/77) had Metastrongylus sp., however, there was no association between its occurrence and the pattern of aTB lesions. The absence of tuberculous lesions in infected animals is worrisome, especially to hunters who handle their carcasses, potentially assuming that the animal is healthy. Studies evaluating other possibilities that can explain the absence of lesions in infected animals should be carried out to better understand these findings. |
| |
| Keywords: | Nematode Bovine tuberculosis Swine Mixed infections Zoonosis Parasite |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
