Seroprevalence,associated risk factors analysis and first molecular characterization of chlamydia abortus among Egyptian sheep |
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| Institution: | 1. Department of Animal Medicine (Infectious Diseases), Faculty of Veterinary Medicine, Benha University, Toukh, 13736, Egypt;2. Animal and Poultry Production, Department of Animal Wealth Development, Faculty of Veterinary Medicine, Benha University, Egypt;3. Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, 13736, Egypt;4. Department of Biological Sciences, Faculty of Science and Humanities, Shaqra University, P.O. Box 1040 Ad-Dawadimi, 11911, Saudi Arabia;1. Department of Biological Sciences, University of Cyprus, PO Box 20537, Nicosia 1678, Cyprus;2. Veterinary Services of Cyprus, Nicosia 1417, Cyprus;3. Medical School, University of Cyprus, Siakoleio Center of Clinical Medicine, 2029 Aglantzia, PO Box 20537, 1678 Nicosia, Cyprus;1. Selcuk University, Department of Microbiology, Faculty of Veterinary Medicine, Konya, Turkey;2. Aksaray University, Department of Microbiology, Faculty of Veterinary Medicine, Aksaray, Turkey;3. Selcuk University, Department of Food Technology, Sarayonu Vocational School, Konya, Turkey;4. Konya Numune Hospital, Department of Microbiology, Konya, Turkey;5. Izmir Katip Celebi University, Faculty of Medicine, Department Of Biostatistics And Medical Informatics, ?zmir, Turkey;1. School of Veterinary Science, The University of Queensland, Gatton, 4343, Australia;2. School of Agriculture and Food Sciences, The University of Queensland, Gatton, 4343, Australia;3. Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, 4001, Australia;1. Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Ruta 50 Km 11, La Estanzuela, 70000, Colonia, Uruguay;2. Instituto Nacional de Tecnología Agropecuaria (INTA), Balcarce, Buenos Aires, Argentina;3. Setor de Patologia Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brasil;4. California Animal Health and Food Safety Laboratory (CAHFS), University of California, Davis, USA;1. University Paris-Est, Anses, Animal Health Laboratory, Bacterial Zoonoses Unit, Maisons-Alfort, France;2. Minnesota Veterinary Diagnostic Laboratory, St. Paul, MN, USA;3. University of Maryland, Electron Microscopy Core Imaging Facility, Baltimore, MD 21201, USA;4. University of Maryland, Department of Microbial Pathogenesis, Baltimore, MD 21201, USA;5. University Paris-Est, Anses, Food Research Laboratory, IdentyPath Platform, Maisons-Alfort, France;6. RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University Jena, Jena, Germany |
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| Abstract: | Chlamydia abortus is one of the most common abortive agents worldwide in sheep. Few studies have been reported C. abortus infection among sheep in Egypt but the available data is scarce. The objective of the present study was to determine the seroprevalence of C. abortus among sheep, the associated risk factors and its molecular characterization. The present study was conducted on 675 sheep in six Governorates at Northern Egypt. Data analysis confirmed the presence of antibodies against C. abortus in 93 out of 675 sheep. The logistic regression model was fitted to identify the associated risk factors with C. abortus infection. The results revealed that C. abortus increased significantly in ewes (OR = 4.04, 95 %CI: 1.44?11.28) during autumn season (OR = 3.6, 95 %CI: 1.64–8.28), in ewes with a history of abortion (OR = 1.4, 95 %CI: 0.87–2.50) and in farm where no lambing pen (OR = 2.2, 95 %CI: 1.30–3.94) or abscence of post abortion measures (OR = 1.96, 95%CI: 1.23-3.12). In addition, age, flock size and exchange of breeding ram had no significant effect on prevalence of chlamydiosis. Also, PCR assay was confirmed presence of C. abortus as accusative pathogen in aborted ewe and the genetic characterization of Egyptian C. abortus strain revealed 100 % identity with another strain from Iraq. A control program should be applied to reduce economic losses and risk of human infection. |
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| Keywords: | Chlamydia abortus ELISA OMP2 gene Phylogenetic analysis Sheep |
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