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New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius
Authors:Zhi-Qiang Bai  Xiuping Lin  Junfeng Wang  Xuefeng Zhou  Juan Liu  Bin Yang  Xianwen Yang  Shengrong Liao  Lishu Wang  Yonghong Liu
Abstract:Four new meroterpenoids (2–5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1–7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.
Keywords:meroterpenoid  Aspergillus flavipes  endophytic fungus
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