Penicibrocazines A–E,Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae |
| |
| Authors: | Ling-Hong Meng Peng Zhang Xiao-Ming Li Bin-Gui Wang |
| |
| Institution: | 1.Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China; E-Mails: (L.-H.M.); (P.Z.); (X.-M.L.);2.College of Earth Science, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China |
| |
| Abstract: | Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A–E (1–5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated by detailed interpretation of NMR and mass spectroscopic data and the structures of compounds 1 and 3 were confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for cytotoxic and antimicrobial activities. Compounds 2–6 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 0.25 to 64 μg/mL. |
| |
| Keywords: | mangrove plant endophytic fungus Pencillium brocae secondary metabolites antimicrobial activity |
|
|
