Immunohistochemical evaluation of a malignant phecochromocytoma in a wolfdog |
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| Authors: | Sako T Kitamura N Kagawa Y Hirayama K Morita M Kurosawa T Yoshino T Taniyama H |
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| Institution: | Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen Univeristy, Ebetsu, Hokkaido, Japan. |
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| Abstract: | A malignant pheochromocytoma with multiple metastases was diagnosed in a 7-year-old male wolfdog that resulted from a cross between an eastern timber wolf (Canis lupus lycaon) and an Alaskan malamute. A yellowish white neoplastic mass approximately 10 cm diameter was found in the right adrenal gland. The neoplasm penetrated through the wall of the caudal vena cava. A diagnosis of pheochromocytoma was established by histopathologic and immunohistochemical procedures. Immunohistochemically, the neoplastic cells expressed chromogranin A, substance P, synaptophysin, Leu-7, protein gene product 9.5, methionine-enkephalin, S100 protein, and galanin. Multiple metastatic tumors were found in the kidneys, spleen, lungs, heart, and liver. |
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