| 实验性脾虚证与自由基代谢的相关性及四君子汤对其的调整作用 |
| |
| 引用本文： | 魏彦明,李文广.实验性脾虚证与自由基代谢的相关性及四君子汤对其的调整作用[J].畜牧兽医学报,2002,33(1):100-104. |
| |
| 作者姓名： | 魏彦明 李文广 |
| |
| 作者单位： | 1. 甘肃农业大学动物医学系,兰州,730070
2. 兰州医学院药理系,兰州,730000 |
| |
| 摘 要： | 分别用小承气汤和利血平复制大鼠脾虚证模型，通过检测血清和心、肝、脾、肾等组织中抗氧化酶SOD和GSHP－Px的活性及脂质过氧化反应终产物MDA含量，研究脾虚证与自由基代谢的相关性及四君子汤对其影响。结果表明：两种方法复制脾虚证模型与对照组比较均表现为SOD活性显著升高（P＜0．05），GSH－Px活性显著降低（P＜0．05）；四君子汤反证治疗组与脾虚证组比较表现为SOD活性显著下降（P＜0．05），GSH－Px活性显著升高（P＜0．05），MDA含量显著降低（P＜0．05），与正常对照组接近。表明大鼠虚证动物模型与体内自由基代谢紊乱，脂质过氧化作用增强存在一定关系，健脾益气方药四君子汤能够提高体内抗氧化酶活性，拮抗自由基对生物膜的过氧化损伤，具有抗脂质过氧化损伤的作用。
|
| 关 键 词： | 脾虚证 SOD GSH－Px MDA 自由基代谢 相关性 四君子汤 抗氧化作用 |
| 文章编号： | 0366-6964(2002)01-0100-05 |
The Relationship between Experimental Spleen Deficiency Syndrome and Free Radicals and the Regulatine Effect of Sijunzi Decoction on it |
| |
| WEI Yan ming ,LI Wen guang.The Relationship between Experimental Spleen Deficiency Syndrome and Free Radicals and the Regulatine Effect of Sijunzi Decoction on it[J].Acta Veterinaria et Zootechnica Sinica,2002,33(1):100-104. |
| |
| Authors: | WEI Yan ming LI Wen guang |
| |
| Institution: | WEI Yan ming 1,LI Wen guang 2 |
| |
| Abstract: | Two kind of spleen deficiency syndrome (SDS) models were induced by injection of reserpine and administration of Xiaochengqi decoction respestively in rats,and Sijunzi decoction was used in treating SDS models.The activity of superoxide dismutase (SOD),glutathione peroxidase (GSH Px) and the contents of malondialdehyde (MDA) in the heart,liver,spleen,kidney and serum,and the protective effects of Sijunzi decoction on it were observed.The experiment results showed that the activity of SOD and the contents of MDA in the SDS model group were obviosly higher than those of the control group (P<0 05),the activity of GSH Px was markedly higher than that of the control group (P<0 05).The Sijunzi decoction could significantly reduce the activity of SOD and the contents of MDA(P<0 05),the activity of GSH Px was obviosly higher than that of the SDS model group (P<0 05).It is suggested that there is close correlation between the SDS and free radicals,and Sijunzi decoction could regulate the metabolic disorder of free radicals. |
| |
| Keywords: | Spleen deficiencysyndrome Rat free radical SOD GSH Px MDA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
