| 三种有机磷农药胚胎期暴露对新生鼠脑组织结构的影响 |
| |
| 引用本文： | 陈伟峰,陈晓萍,陈文珍.三种有机磷农药胚胎期暴露对新生鼠脑组织结构的影响[J].农药学学报,2011,13(4):369-374. |
| |
| 作者姓名： | 陈伟峰 陈晓萍 陈文珍 |
| |
| 作者单位： | 1.浙江工业大学 生物与环境工程学院,杭州 310014 |
| |
| 基金项目： | 国家自然科学基金资助项目(30972446). |
| |
| 摘 要： | 探讨了3种常用的有机磷农药胚胎期暴露对新生鼠脑组织结构的影响。在母鼠妊娠期7.5～11.5 d时,连续5 d每天分别经皮下注射2 mg/kg bw的二嗪磷(diazinon)、2 mg/kg bw的毒死蜱(chlorpyrifos)及50 mg/kg bw乙酰甲胺磷(acephate),显微镜下观察并计数大脑皮层S1区胶质细胞和神经元数量及比率,以及海马CA1、CA3区锥体细胞的数量及体积密度。结果表明,二嗪磷与毒死蜱处理分别使得大脑皮层S1区胶质细胞数减少了14.29%和21.43%;毒死蜱处理导致胶质细胞与神经元比率下降了24.19%;二嗪磷与毒死蜱处理后海马CA1区锥体细胞数量分别下降了9.30％与20.93％,毒死蜱处理后锥体细胞体积密度下降了27.05％;二嗪磷与毒死蜱处理后海马CA3区锥体细胞数量分别下降了22.22％和19.44％,锥体细胞体积密度分别下降了23.54％和18.98％;而乙酰甲胺磷对新生鼠大脑皮层与海马细胞均无明显影响。
|
| 关 键 词： | 有机磷农药 胚胎期 鼠 脑组织 皮层S1区 海马区 |
| 收稿时间： | 2011/1/25 0:00:00 |
| 修稿时间： | 2011/4/22 0:00:00 |
Effects of prenatal exposure of three organophosphorus pesticides on neonatal brain structure |
| |
| CHEN Wei-feng,CHEN Xiao-ping and CHEN Wen-zhen.Effects of prenatal exposure of three organophosphorus pesticides on neonatal brain structure[J].Chinese Journal of Pesticide Science,2011,13(4):369-374. |
| |
| Authors: | CHEN Wei-feng CHEN Xiao-ping and CHEN Wen-zhen |
| |
| Institution: | 1.College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China |
| |
| Abstract: | Effects of prenatal exposure of three organophosphorus pesticides on neonatal brain structure in mice were investigated.2 mg/kg bw of diazinon,2 mg/kg bw of chlorpyrifos and 50 mg/kg bw of acephate were injected subcutaneously daily during gestation days 7.5-11.5 of ICR mice.Quantitative morphology in hippocampus and somatosensory cortex were measured.The results showed that diazinon and chlorpyrifos caused glia number in somatosensory cortex reduced by 14.29% and 21.43%,respectively,and chlorpyrifos caused... |
| |
| Keywords: | organophosphorus pesticide embryonic period mouse brain structure somatosensory cortex hippocampus |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《农药学学报》浏览原始摘要信息 |
| 点击此处可从《农药学学报》下载免费的PDF全文 |
