| 氟苯尼考在鲟鱼体内的药物代谢动力学研究 |
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| 引用本文： | 潘红艳,郭娇娇,杨虎,宫智勇,李谷.氟苯尼考在鲟鱼体内的药物代谢动力学研究[J].水产科学,2011,30(7):373-377. |
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| 作者姓名： | 潘红艳 郭娇娇 杨虎 宫智勇 李谷 |
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| 作者单位： | 1. 武汉工业学院,食品科学与工程学院,湖北,武汉,430023
2. 中国水产科学研究院,长江水产研究所,湖北,荆州,434000 |
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| 基金项目： | "十一五"国家科技支撑计划项目，国家科技支撑计划项目，武汉工业学院校研究生创新基金资助项目 |
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| 摘 要： | 采用高效液相色谱检测组织中药物含量,研究水温在(20±1)℃时,杂交鲟经口一次性给予10 mg/kg氟苯尼考后在血液、肌肉、肝脏中的代谢规律.试验结果表明,氟苯尼考经口给药后在鲟鱼血液中的代谢属于一级吸收一室模型,在肌肉和肝脏中属于一级吸收二室模型,且分布广泛,代谢迅速.主要药代动力学参数如下:血液、肌肉、肝脏中的达峰...
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| 关 键 词： | 氟苯尼考 药物代谢动力学 杂交鲟 |
Pharmacokinetics of a Chemical Florfenicol in Sturgeon |
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| PAN Hong-yan,GUO Jiao-jiao,YANG Hu,GONG Zhi-yong,LI Gu.Pharmacokinetics of a Chemical Florfenicol in Sturgeon[J].Fisheries Science,2011,30(7):373-377. |
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| Authors: | PAN Hong-yan GUO Jiao-jiao YANG Hu GONG Zhi-yong LI Gu |
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| Institution: | 1.College of Food Science and Engineering,Wuhan Polytechnic University,Wuhan 430023,China;2.Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Jingzhou 434000,China) |
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| Abstract: | The pharmacokinetics of florfenicol were studied in blood,muscle and liver in hybrid(Acipenser schrenckii×Huso dauricus) sturgeon sampled after intravenous injection at single dose of 10 mg/kg body weight by HPLC,and the data were analyzed by pharmacokinetics computer program 3P97.The results showed that the concentration-time course of the florfenicol was described by one-compartment model with 1st order absorption in the blood and two-compartment model with 1st order absorption in the muscle and liver,with wide distribution and rapid metabolism.The main pharmacokinetics parameters in blood,muscle and liver were found as following:Cmax 6.43,5.81,and 6.062 μg/ml;Tmax 9.84,8.88,and 0.51 h;t1/2α29,4.61,and 0.27 h;t1/2β 9.45,21.69,and 11.04 h;AUC 169.02,227.41,and 50.56 mg/(L·h);V/f 0.81,1.07,and 0.80;CL/f(s) 0.059,0.051,and 0.2 L/kg;recovery≥90%,R2=0.9996. |
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| Keywords: | florfenicol pharmacokinetics hybrid sturgeon(Acipenser schrenckii×Huso dauricus) |
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