Study on the Separation, Extraction of Lycopene and Its Effects on Cell Cycle |
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| Authors: | WANG Qiang ZHAO Wen-en QIAO Xu-guang HAN Ya-shan |
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| Abstract: | The separation, extraction of lycopene and its effects on the proliferation and cells cycle of the chemical-induced cells were investigated in order to research on its extraction method and the mechanism in inhibiting neoplastic transformation. The best extraction condition of lycopene with super-critical carbon dioxide was under the pressure of 25MPa, the temperature of 50℃ and duration of 3. 0h. Lycopene could inhibit cell growth rate and cells proliferation significantly, while increase the cell numbers of G1-phase and decrease that of S-phase and G2 +-M-phase. The potency of the effects of lycopene on cells cycle might be one of the important reasons for inhibiting neoplastic transformation. |
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| Keywords: | Lycopene Super-critical carbon dioxide Cell cycle |
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