Immunolocalization of basic fibroblast growth factor in porcine epiphyseal growth plate |
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| Institution: | 1. Department of Poultry Science, The Pennsylvania State University, University Park, Pennsylvania 16802-3501 USA;7. United States Department of Agriculture, Growth Biology Laboratory, Agricultural Research Service, Beltsville, Maryland 20705 USA;1. Department of Micro Engineering, Graduate School of Engineering, Kyoto University, Kyoto Daigaku-katsura, Nishikyo-ku, Kyoto, 615-8530, Japan;2. Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan;3. Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University, Yoshida-Konoecho, Sakyo-ku, Kyoto, 606-8501, Japan;1. Department of Micro Engineering, Graduate School of Engineering, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan;2. Department of Biosystems Science, Institute for Life and Medical Sciences, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan;3. Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo, Kyoto, 606-8507, Japan |
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| Abstract: | Recent evidence clearly indicates that basic fibroblast growth factor (bFGF) signal transduction is essential for normal skeletal development. Here, we report that bFGF and its receptor are specifically localized in the terminal hypertrophic chondrocytes of the porcine epiphyseal growth plate, the tissue responsible for longitudinal bone growth. Similar observations were obtained with the chondrocytes immediately adjacent to resorbing blood vessels in the secondary center of ossification of the epiphysis. These results are consistent with a recent proposal that bFGF functions in coupling osteogenesis with chondrogenesis by attracting the vascular invasion of cartilage from adjacent trabecular bone. |
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