| 脂质体儿茶素在家兔体内的生物利用度与药物动力学 |
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| 引用本文： | 孙志良,刘湘新,林亲录,刘自逵,刘进辉,何湘蓉.脂质体儿茶素在家兔体内的生物利用度与药物动力学[J].茶叶科学,2004,24(1):44-48. |
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| 作者姓名： | 孙志良 刘湘新 林亲录 刘自逵 刘进辉 何湘蓉 |
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| 作者单位： | 1. 湖南农业大学动物科技学院,湖南,长沙,410128
2. 湖南农业大学食品科技学院,湖南,长沙,410128 |
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| 基金项目： | 湖南省自然科学基金(01JJY2096)资助 |
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| 摘 要： | 取健康家兔10只,随机分为2组,单剂量静注和灌服脂质体儿茶素(Catechin Liposome)25mg/kg。用高效液相色谱法测定血浆中儿茶素原药质量浓度。房室模型分析表明:健康家兔静注儿茶素脂质体的药时数据符合无吸收二室开放模型,主要药物动力学参数为:t1/2α0.18±0.01 h,t1/2β1.52±0.08 h,Vd4.48±0.24L,ClB2.05±0.07L/h,AUC29.20±1.00 mg/(L.h),K101.64±0.19h-1,K211.08±0.06h-1,K121.61±0.19h-1。健康家兔灌服脂质体儿茶素的药时数据符合一级吸收一室开放模型,主要药物动力学参数为:t1/2ka 0.27±0.03 h,t1/2ke 1.72±0.04 h,tmax0.87±0.05 h,Cmax6.53±0.62 mg/L,AUC 25.90±1.34 mg/(L.h),F 88.60±5.73%。脂质体儿茶素在健康家兔体内的药动学特征是:吸收迅速,达峰时间较短,消除慢,半衰期延长,表现分布容积大,口服生物利用度高。结果表明:儿茶素经脂质体包封后,药物动力学及组织分布均发生了明显改变。
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| 关 键 词： | 儿茶素 药物动力学 脂质体 家兔 |
| 文章编号： | 1000-369X(2004)01-044-05 |
| 修稿时间： | 2003年3月6日 |
Pharmacokinetics and Bioavailability of Catechin Liposome in Rabbits |
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| SUN Zhi-liang,Liu Xiang-xin,Ling Qin-lu,Liu Zi-kui,Liu jin-fei,He Xiang rong.Pharmacokinetics and Bioavailability of Catechin Liposome in Rabbits[J].Journal of Tea Science,2004,24(1):44-48. |
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| Authors: | SUN Zhi-liang Liu Xiang-xin Ling Qin-lu Liu Zi-kui Liu jin-fei He Xiang rong |
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| Institution: | SUN Zhi-liang1,Liu Xiang-xin1,Ling Qin-lu2,Liu Zi-kui1,Liu jin-fei1,He Xiang rong1 |
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| Abstract: | Pharmacokinetics and bioavailability of Catechin Liposome were studied in 10 healthy rabbits following single intravenous (25mg/kg) and oral administration (25mg/kg)of the drug. Plasma concentrations of. Catechin Liposome were determined by high-performance liquid chromatography. The concentration-time data were fitted to a two-compartment model following a single intravenous injection in rabbits. The main pharmacokinetic parameters were as follows: distribution half-life (t1/2α) (0.18±0.01)h,elimination half-life (t1/2β) (1.52±0.08)h,apparent distribution volume (Vd) (4.48±0.24)L total body clearance (ClB) (2.05±0.07)L/h,the area under curve (AUC) (29.20±1.00)mg/(L.h). The drug concentration-time data also were fitted to a one-compartment open model with first order absorption after a single oral administration Catechin Liposome. The pharmacokinetic parameters were as follows: t1/2kα (0.27±0.03)h, t1/2ke(1.72±0.04)h, tmax (0.87±0.05) h, Cmax 6.53±0.62 mg/L, AUC 25.90±1.34 mg/(L.h), bioavailability F 88.60±5.73%. Pharmacokinetic characteristics of Catechin Liposome in healthy rabbits showed a rapid absorption, the time to reach Cmax is short, slow elimination, long half-life, large apparent distribution volume, and high bioavailability of oral administration. The results showed:after Catechin was prepared in liposome form, the tissue distribution and pharmacokinetics were changed significantly. |
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| Keywords: | Catechin Liposome Pharmacokinetics Bioavailability Rabbits |
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