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Stimulation by phagocytosis of the deiodination of L-thyroxine in human leukocytes |
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| Authors: | K A Woeber G F Doherty S H Ingbar |
| Abstract: | Intact human leukocytes actively deiodinate L-(131)1] thyroxine, producing mainly inorganic (131)1 and chromatographically immobile (131)1-labeled origin material. When phagocytosis is induced, the deiodination is enhanced, a suggestion that deiodination in mediated by a peroxidase-hydrogen peroxide system. l-Thyroxine can serve as a source of iodine for iodination reactions within the leukocyte. |
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