| 多潘立酮微乳的制备及质量评价 |
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| 引用本文： | 秦金淼,李引亁,薛琴,薛芬,张海亮,庞丽娜,王倩.多潘立酮微乳的制备及质量评价[J].西北农业学报,2009,18(3):33-37. |
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| 作者姓名： | 秦金淼 李引亁 薛琴 薛芬 张海亮 庞丽娜 王倩 |
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| 作者单位： | 西北农林科技大学,动物医学院,陕西杨凌,712100 |
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| 摘 要： | 通过滴定法绘制伪三元相图,根据相图优选处方,并初步考察微乳制剂的稳定性、形态粒径和理化性质.用紫外分光光度(UV-Vis)法测定微乳中多潘立酮的含量.结果表明,制备出的多潘立酮微乳处方是聚氧乙烯氢化蓖麻油(RH-40)/肉豆蔻酸异丙酯(IPM)/多潘立酮/蒸馏水.微乳稳定,透射电镜下呈圆球形,分布均匀,平均粒径12.4 nm.在1～50 μg/mL浓度范围内,浓度与吸光度的线性关系良好,平均回收率为(99.41±1.17)%,RSD为1.18%(n=5).多潘立酮微乳应低温(4℃)、避光保存.该处方设计合理,方法可靠.
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| 关 键 词： | 多潘立酮 微乳 (伪)三元相图 质量评价 |
| 收稿时间： | 2008/11/3 0:00:00 |
| 修稿时间： | 2009/1/4 0:00:00 |
Preparation and Quality Evaluation of Domperidone Microemulsion |
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| QIN Jinmiao,LI Yinqian,XUE Qin,XUE Fen,ZHANG Hailiang,PANG Lina and WANG Qian.Preparation and Quality Evaluation of Domperidone Microemulsion[J].Acta Agriculturae Boreali-occidentalis Sinica,2009,18(3):33-37. |
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| Authors: | QIN Jinmiao LI Yinqian XUE Qin XUE Fen ZHANG Hailiang PANG Lina and WANG Qian |
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| Institution: | College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China |
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| Abstract: | |
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| Keywords: | Domperidone Microemulsion Pseudo-ternary phase diagram Quality evaluation |
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