For dynamic QTLs being located preliminarily and genetic analysis of wheat grain filing rate and thousand grain weight in different growth periods, RIL population (F9) was used for material gained from 6044×01-35 crossing. Mapmaker/version 3.0 was used to draw gene map and to calculate genetic distance among markers. Analysis of QTL effect was done by Win QTL Cart 2.5 combined with field phenotype data. The results showed that, thirteen QTLs were found in four different chromosomes. Most of QTLs were located in chromosome-2A, others were in 6A, 5A, 4A. Two grain weight QTLs were found with 9% to 33% explanation for variation. Three mean grain filling rate QTLs were found with 6% to 18% explanation for variation. One max grain filling rate QTL was found which account for 11% of variation. One period for max grain filling rate QTL was located in chromosome-6A explaining 7% phonotype variation. One first period and a fourth period grain filling rate QTL was found with 12% and 16% explanation. Two third and two fifth period grain filling rate QTLs were found with 8%-9% and 9%-10% explanation for variation dynamic QTLs locations of different periods for grain filling rate and grain weight showed the gene expression characteristics of time and space. That would lay the foundation for subtle location of grain filling rate and grain weight in wheat and for molecular marker assisted selection.