| 纤毛纲动物在环境污染物毒性早期监测和评价中的应用 |
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| 引用本文： | 李国锋,刘诗燕,杨建春,陈帅,常逢彤,周海龙.纤毛纲动物在环境污染物毒性早期监测和评价中的应用[J].热带生物学报,2020,11(3):361-367. |
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| 作者姓名： | 李国锋 刘诗燕 杨建春 陈帅 常逢彤 周海龙 |
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| 作者单位： | 1.武汉大学 药学院，武汉 430071 |
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| 摘 要： | 与传统的物理和化学方法相比，全活细胞在环境毒理监测和评估中具有不可替代的优势。由于纤毛纲动物具有易于培养、个体较大、便于观察、真核且无细胞壁等特点，因此，特别适合用于环境毒理监测。笔者详细介绍了纤毛纲动物在重金属、持久性有机污染物（POPs）和纳米颗粒污染物质（NP）中的监测进展，并探讨了纤毛纲动物在应答污染物胁迫的响应机理，以及将纤毛纲动物研制成生物芯片早期监测的可能性。
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| 关 键 词： | 纤毛纲 毒性 重金属 POPs 纳米污染颗粒 全活细胞生物监测器 |
| 收稿时间： | 2019-06-20 |
Application of the Ciliata in Early Monitoring and Evaluation of Ecological Toxicity |
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| Institution: | 1.School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, China2.College of Life Science and Pharmacy, Hainan University, Haikou, Hainan 570228, China3.Anhui Microanaly Genentech Co., Ltd., Hefei, Anhui 238000, China4.Fengjie County Forestry Bureau, Chongqing, 404600, China |
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| Abstract: | Compared to traditional chemical and physical methods, the whole-cell biosensor has an irreplaceable advantage in the monitoring and evaluation of environmental toxicology. The Ciliata is the best in the whole-cell living biosensor because of its easy culture, large size for easy observation, eukaryotic and no cell wall. The monitoring performance of the Ciliata in heavy metals, persistent organic pollutants (POPs) and nanoparticle pollutants (NP) was described, and the metabolic mechanism of the Ciliata in exposure to these pollutants and the possibility of using the Ciliata organism as a standard whole-cell living biosensor chip to monitor early environmental pollution were discussed. In summary, the Ciliata Bio-toxicity Assessment System is an ideal early monitoring and evaluation system for environmental pollutants, but the research on the Ciliata is still at a relatively early stage, and a lot of research work needs to be done. |
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