| 复方丙酸氯倍他索乳膏对小型猪皮肤长程涂布的毒性观察 |
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| 引用本文： | 王振超,黄壮雄,许建鹏,陈英,郑丽燕,王晖.复方丙酸氯倍他索乳膏对小型猪皮肤长程涂布的毒性观察[J].湛江医学院学报,2004,22(6):563-565. |
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| 作者姓名： | 王振超 黄壮雄 许建鹏 陈英 郑丽燕 王晖 |
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| 作者单位： | 广东省湛江市霞湖医院,广东湛江,524013;广东医学院药理教研室,广东湛江,524023 |
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| 摘 要： | 目的：观察复方丙酸氯倍他索乳膏对小型猪皮肤长程涂布的毒性。方法：32只巴马小型猪随机分为低剂量组、中剂量组、高剂量组、对照组4组，每组8只。每日涂药1次，封包6h，连续8周，比较给药前后的动物外观体征、活动状态、体重增加、脏器系数、血液学常规、血液生化学、清晨血清皮质醇浓度，以及皮肤和内脏的病理改变。结果：低、中、高三种剂量对实验动物血液学常规、血液生化学、外观体征、活动状态，体重增加、脏器系数均无不良影响，涂药部位皮肤和心、肝，肾，肺、胃未见异常。但涂药部位肾上腺皮肤萎缩，血清皮质醇浓度下降，其程度随剂量和疗程增加而加强，停药2周后上述改变均可自行恢复。结论：丙酸氯倍他索引起毒性的靶器官是肾上腺皮质和涂药部位皮肤，剂量增加、时间延长其不良反应也增强，停药后可自行恢复。
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| 关 键 词： | 氯倍他索/毒性 软膏 猪 |
| 文章编号： | 1005-4057(2004)06-0563-03 |
| 修稿时间： | 2004年9月20日 |
The study of toxicity of long-term topical use of compound clobetasol propionate cream in mini-pigs |
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| WANG Zhen-chao,HUANG Zhuang-xiong,XU Jian-peng,CHEN Ying,ZHENG Li-yan,WANG Hui.The study of toxicity of long-term topical use of compound clobetasol propionate cream in mini-pigs[J].Journal of Guangdong Medical College,2004,22(6):563-565. |
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| Authors: | WANG Zhen-chao HUANG Zhuang-xiong XU Jian-peng CHEN Ying ZHENG Li-yan WANG Hui |
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| Institution: | WANG Zhen-chao1,HUANG Zhuang-xiong1,XU Jian-peng1,CHEN Ying2,ZHENG Li-yan2,WANG Hui2 |
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| Abstract: | Objective: To study the long-term toxicity of a proprietary topical clobetasol propionate combination cream (CPCC) in swine. Methods: 32 pigs were randomly divided into 3 experimental groups and 1 control group. Animals in each experimental groups received topical application of 0.05, 0.1 or 0.2 g/kg of the 0.05% CPCC cream for 8 weeks. Animals in control group received 0.2 g/kg vehicle for the same duration. Behavior and body weight changes of the animals were observed daily. Serum cortisol level, complete blood count, blood biochemistry profile were measured at 0, 4, 8 and 10 weeks during the study. Pathological examinations were performed at 8 and 10 weeks,rexpoctively after the animals were sacrificed. Results: There were no significant differences in serum cortisol levels between control animals and animals receiving 0.05 or 0.1 g/kg 0.05% CPCC after 4-week treatment. The serum cortisol levels in animals receiving 0.2 g/kg 0.05% CPCC were significantly lower than that in control animals after 4-week treatment. After 8-week application of 0.05% CPCC, the serum cortisol levels in all experimental groups were significantly lower than that in control group. There were no significant differences in serum cortisol levels between control and experimental animals two weeks after 0.05% CPCC withdrawal. Atrophy of the skin and adrenal glands were observed in animals receiving 8 week 0.05% CPCC treatment. No significant differences were observed in the behavior, body weight change, complete blood count, blood biochemistry profile, and liver and kidney function profiles between control and experimental animals. Conclusion: Suppression of the hippocampus-pituitary-adrenal (HPA) axis by topical application of the 0.05% CPCC is dose and duration- dependent. Toxicity of 0.05% CPCC can be avoided by controlling the dosage and treatment duration. If long-term treatment is necessary, functions of the HPA axis should be monitored. |
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| Keywords: | clobetasol propionate/toxicity ointment pig |
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