| 噁喹酸在凡纳滨对虾体内药动学和对弧菌的体外药效 |
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| 引用本文： | 王元,殷桂芳,符贵红,周俊芳,沈锦玉,房文红.噁喹酸在凡纳滨对虾体内药动学和对弧菌的体外药效[J].水产学报,2016,40(3):512-519. |
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| 作者姓名： | 王元 殷桂芳 符贵红 周俊芳 沈锦玉 房文红 |
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| 作者单位： | 1. 中国水产科学研究院东海水产研究所,农业部东海与远洋渔业资源开发利用重点实验室,上海200090;2. 中国水产科学研究院东海水产研究所,农业部东海与远洋渔业资源开发利用重点实验室,上海200090;上海海洋大学水产与生命学院,上海201306;3. 浙江省淡水水产研究所,浙江湖州,313001 |
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| 基金项目： | 公益性行业(农业)科研专项(201203085)；中国水产科学研究院基本科研业务费资助(2013A0603)。 |
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| 摘 要： | 采用高效液相色谱法,研究了复方噁喹酸粉药饵投喂在凡纳滨对虾体内药动学和组织中消除规律,同时检测了噁喹酸对对虾源弧菌的最小抑菌浓度(MIC),建立了药动/药效(PK/PD)关系,提出了用药方案和休药期建议。结果显示,复方噁喹酸粉拌饵投喂给药,噁喹酸给药剂量为30 mg/kg(体质量),凡纳滨对虾血浆噁喹酸浓度—时间关系曲线均符合一级吸收二室开放动力学模型。血淋巴中噁喹酸达峰浓度(Cmax)、达峰时间(Tmax)、曲线下面积(AUC0-24)和消除半衰期(t1/2z)分别为14.70 mg/L、2 h、244.6 mg/(L·h)和18.56 h;肌肉、肝胰腺和鳃的峰浓度(Cmax)分别为4.11、17.20和7.01 mg/kg,消除半衰期(t1/2z)分别为10.71、12.31和16.75 h。噁喹酸对132株弧菌的MIC主要分布在0.15~1.25μg/m L,MIC50和MIC90分别为0.62和1.25μg/m L。PK/PD相互关系参数Cmax/MIC90和AUC0-24/MIC90分别为11.76和195.7。研究表明,噁喹酸以30 mg/(kg体质量)剂量药饵给药,凡纳滨对虾能很好地吸收噁喹酸,可以有效地防治弧菌引起的细菌性疾病。
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| 关 键 词： | 凡纳滨对虾 弧菌 噁喹酸 药动学 体外药效 |
| 收稿时间： | 2015/3/11 0:00:00 |
| 修稿时间： | 2015/5/25 0:00:00 |
Pharmacokinetics of oxolinic acid in the Pacific white shrimp (Litopenaeus vannamei) and in vitro antimicrobial activity on Vibrios |
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| WANG Yuan,YIN Guifang,FU Guihong,ZHOU Junfang,SHEN Jinyu and FANG Wenhong.Pharmacokinetics of oxolinic acid in the Pacific white shrimp (Litopenaeus vannamei) and in vitro antimicrobial activity on Vibrios[J].Journal of Fisheries of China,2016,40(3):512-519. |
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| Authors: | WANG Yuan YIN Guifang FU Guihong ZHOU Junfang SHEN Jinyu and FANG Wenhong |
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| Institution: | East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of East China Sea and Oceanic Fishery Resources Exploitation and Utilization,Ministry of Agriculture,East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of East China Sea and Oceanic Fishery Resources Exploitation and Utilization,Ministry of Agriculture,East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of East China Sea and Oceanic Fishery Resources Exploitation and Utilization,Ministry of Agriculture,East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of East China Sea and Oceanic Fishery Resources Exploitation and Utilization,Ministry of Agriculture,Zhejiang Institute of Freshwater Fisheries,East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of East China Sea and Oceanic Fishery Resources Exploitation and Utilization,Ministry of Agriculture,East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of East China Sea and Oceanic Fishery Resources Exploitation and Utilization,Ministry of Agriculture |
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| Abstract: | |
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| Keywords: | Litopenaeus vannamei Oxolinic acid Pharmacokinetics in vitro Pharmacodynamics Vibrios Withdrawal time |
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