Masitinib for the treatment of canine atopic dermatitis: a pilot study |
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| Authors: | Jenise Daigle Alain Moussy Colin D Mansfield Olivier Hermine |
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| Institution: | 1.Austin Veterinary Dermatology,Round Rock,USA;2.AB Science S.A.,Paris,France;3.Service d’Hematologie, CNRS, UMR 8147, Centre de reference des mastocytoses,Université Paris V René Descartes, H?pital Necker,Paris,France |
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| Abstract: | There is an on-going need to identify medications suitable for the long-term treatment of canine atopic dermatitis (CAD).
Masitinib mesilate is a potent and selective tyrosine kinase inhibitor of the c-KIT receptor. A strong relationship exists
between the SCF/c-KIT pathway and pathogenesis of CAD, suggesting that masitinib may potentially fulfil the above role. This
study reports on an uncontrolled pilot study of masitinib in CAD. Masitinib was administered orally to 11 dogs at a mean dose
of 11.0 ± 1.83 mg/kg/day (free base) for 28 days. Treatment response was assessed by evolution of clinical appearance according
to a modified version of the Canine Atopic Dermatitis Extent and Severity Index (mCADESI), pruritus scale and surface area
of lesions. Masitinib improved CAD with a mean reduction in mCADESI of 50.7 ± 29.8% (95% C.I. = 29.4–72.0; p = 0.0004) at
day 28 relative to baseline, with 8/10, 8/10 and 4/10 dogs showing improvement of ≥33%, ≥40% and ≥50%, respectively. Improvement
was further evidenced by a decrease in pruritus score and the surface area of lesions. No serious or severe adverse events
occurred during this trial, although 6/11 dogs presented with mild to moderate treatment related adverse events. There is
sufficient compelling evidence to warrant further investigation. |
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