A study of liver function in rats with mirex-induced enlarged livers |
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| Authors: | Keith M Robinson James D Yarbrough |
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| Institution: | Department of Zoology, Mississippi State University, Mississippi State, Mississippi 39762 USA |
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| Abstract: | The functional capacity of a mirex-induced, enlarged liver was studied in rats. The tests used were sulfobromophthalein clearance, hepatic cytochrome P-450 concentration, serum total protein concentration and electrophoretic pattern, serum total lipid concentration, serum glucose concentration, and the liver response to epinephrine. There was no indication of a loss of functional capacity in the enlarged liver. Sulfobromophthalein clearance and microsomal cytochrome P-450 concentration indicated an increase in total liver functional capacity. We conclude that mirex is not a direct hepatotoxin producing generalized parenchymal cell damage. |
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