Polyoxygenated Steroids from the Octocoral Leptogorgia punicea and in Vitro Evaluation of Their Cytotoxic Activity |
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| Authors: | Maria Izabel G Moritz Lucas Louren?o Marostica éverson M Bianco Maria Tereza R Almeida Jo?o L Carraro Gabriela M Cabrera Jorge A Palermo Cláudia M O Sim?es Eloir P Schenkel |
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| Institution: | 1Post-Graduation Program in Pharmacy, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil; E-Mails: (M.I.G.M.); (L.L.M.); (E.M.B.); (M.T.R.A.); (C.M.O.S.);2Invertebrates Department, National Museum, Federal University of Rio de Janeiro, Rio de Janeiro 20940-040, RJ, Brazil; E-Mail: ;3UMYMFOR—Department of Organic Chemistry, FCEN, University of Buenos Aires, Buenos Aires C1428EGA, Argentina; E-Mails: (J.A.P.); (G.C.) |
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| Abstract: | Five new polyoxygenated marine steroids—punicinols A–E (1–5)—were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel. |
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| Keywords: | Leptogorgia punicea octocoral polyoxygenated steroids cytotoxic effects A549 cells lung cancer cells |
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