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Three New Asperentin Derivatives from the Algicolous Fungus Aspergillus sp. F00785
Authors:Qian Tang  Kai Guo  Xiao-Yang Li  Xiu-Ying Zheng  Xiang-Jian Kong  Zhong-Hui Zheng  Qing-Yan Xu  Xianming Deng
Abstract:Three new asperentin-type compounds, 6-O-α-d-ribosylasperentin (1) and 6-O-α-d-ribosyl-8-O-methylasperentin (2) and 5-hydroxyl-6-O-methylasperentin (3), along with asperentin (4) and its known analogues (5–9), were isolated from a halotolerant Aspergillus sp. strain F00785, an endotrophic fungus from marine alga. Their structures were determined using extensive NMR and HRESIMS spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of compound 9. Compound 4 exhibited highly potent inhibitory activity against crop pathogens, Colletotrichum gleosporioides Penz. and Colletotrichum gleosporioides (Penz.) Sacc.
Keywords:asperentin  endophytic fungus  crop pathogen  α  -d-ribofuranose
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