|
|||||
|
|
Evaluation of the effect of ketoprofen on experimentally induced ephemeral fever in dairy heifers |
|
| Authors: | DC FENWICK RCW DANIEL |
| Institution: | Department of Farm Animal Medicine and Production, The University of Queensland, Queensland 4072 |
| Abstract: | Objective To evaluate ketoprofen for the therapy of ephemeral fever. Design A blind controlled clinical trial. Animals Sixteen cattle (one immature Holstein bull, eight Holstein and seven Jersey heifers). Procedure Ephemeral fever was induced by the intravenous injection of blood leucocyte layer from a clinical case. Ketoprofen solution or a coded placebo was injected intramuscularly at the rate of 3 mg/kg daily for three days. Results Ketoprofen reversed locomotor dysfunctions significantly compared with controls, but did not have any effect on rectal temperatures, leucocyte counts, plasma fibrinogen concentrations, ionised Ca-concentrations or the presence of dyspnoea. Conclusion Ketoprofen is a safe and effective drug for the treatment of locomotor symptoms of milk fever, but has no effect on the duration of clinical respiratory abnormalities. |
| Keywords: | Ephemeral fever ketoprofen cattle |