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| 口服疫苗抗原递送载体Lactococcus lactis NZ9000研究进展 | |
| 引用本文： | 任大勇,李昌.口服疫苗抗原递送载体Lactococcus lactis NZ9000研究进展[J].中国兽药杂志,2012,46(6):53-56. |
| 作者姓名： | 任大勇 李昌 |
| 作者单位： | 1. 吉林农业大学食品科学与工程学院,长春130118 军事医学科学院军事兽医研究所,长春130122 2. 军事医学科学院军事兽医研究所,长春,130122 3. 吉林大学农学部畜牧兽医学院,长春,130062 4. 吉林农业大学食品科学与工程学院,长春,130118 |
| 基金项目： | 国家自然科学基金(81001342)；吉林省自然科学基金项目(201015116)；吉林省高新技术产业发展项目(2010)；长春市科技特派员行动计划(09KT04) |
| 摘 要： | 综述了基因工程菌Lactococcus lactis NZ9000在基因组学、安全性、功能性、疫苗载体构建、菌株改造等方面的研究进展，对NZ9000作为口服疫苗载体的表达系统进行了评述，展望了其在生物制药、疫苗开发和食品工业等领域的应用前景，并对今后研究的发展方向做了分析。 |
| 关 键 词： | 口服疫苗 递送载体 乳酸乳球菌NZ9000 |
| 收稿时间： | 2011/12/8 0:00:00 |
| 修稿时间： | 2012/3/15 0:00:00 |
Advancement of Lactococcus lactis NZ9000 as oral vaccine delivery vehicle |
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| REN Da-yong and.Advancement of Lactococcus lactis NZ9000 as oral vaccine delivery vehicle[J].Chinese Journal of Veterinary Drug,2012,46(6):53-56. | |
| Authors: | REN Da-yong and |
| Institution: | College of Food Science and Engineering,Jilin Agricultural University, |
| Abstract: | Advances in genomics,safety,functionality,vaccine vehicle construction and strain improvement of genetically engineered bacteria Lactococcus lactis NZ9000 were reviewed.The gene expression system of NZ9000 as oral vaccine delivery vehicle was discussed and its application prospects in the fields of bio-pharmaceuticals,vaccine development and food industry were proposed and its research development in the future was also briefly analyzed. |
| Keywords: | oral vaccine delivery vehicle L lactis NZ9000 |
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