| 卡洛芬注射液抗炎、镇痛效果及皮肤刺激性观察 |
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| 引用本文： | 邱梅,郝智慧.卡洛芬注射液抗炎、镇痛效果及皮肤刺激性观察[J].中国兽药杂志,2012,46(6):23-26. |
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| 作者姓名： | 邱梅 郝智慧 |
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| 作者单位： | 1. 青岛康地恩药业股份有限公司,山东青岛,266061
2. 青岛农业大学化学与药学院,山东青岛,266111 |
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| 摘 要： | 探讨卡洛芬注射液的抗炎、镇痛作用与皮肤刺激性。以市售托芬那酸注射液为对照药物,抗炎作用采用小鼠耳肿胀法、大鼠踝关节肿胀法,镇痛作用采用小鼠热板法、小鼠醋酸扭体法,刺激性采用兔的皮肤刺激试验考察卡洛芬注射液I、II的抗炎、镇痛作用与刺激性。结果显示,各给药组对二甲苯所致的小鼠耳炎具有明显的抑制作用,且与生理盐水组差异显著(P<0.05);可抑制甲醛所致的大鼠踝关节肿胀,托芬那酸组的肿胀抑制率最高,其次为卡洛芬I组。卡洛芬I组和托芬那酸组在15、30 min时均可有效延长小鼠热板痛阈值;卡洛芬II组没有明显镇痛效果。卡洛芬I组和II组对小鼠扭体的潜伏期没有明显改变,但扭体次数相对较少,扭体抑制率分别为34.7%和17.5%。托芬那酸组第一次扭体的潜伏期较长,扭体抑制率为42.6%。兔的皮肤刺激性试验各给药组均未出现不良反应。卡洛芬I组药效快,抗炎、镇痛效果显著,安全无刺激性,效果优于卡洛芬II组。
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| 关 键 词： | 卡洛芬注射液 托芬那酸注射液 抗炎 镇痛 皮肤刺激性 |
| 收稿时间： | 2011/12/20 0:00:00 |
| 修稿时间： | 2012/2/16 0:00:00 |
Effects Observation of Anti-inflammatory and Analgesic and Skin Irritation of Carprofen Injection |
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| QIU Mei and.Effects Observation of Anti-inflammatory and Analgesic and Skin Irritation of Carprofen Injection[J].Chinese Journal of Veterinary Drug,2012,46(6):23-26. |
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| Authors: | QIU Mei and |
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| Institution: | Continent Pharmaceutical CO,LTD,Shandong, |
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| Abstract: | To study the effects of anti - inflammatory and analgesic and skin irritation of two kinds of carprofen injection with tolfenamic acid injection by contrast, the anti - inflammatory effects were investigated by the methods of xylol induced auriclate tumefaction on mice, carrageenin induced foot swelling on rats. The analgesic effects were observed by the hot -plate test and writhing with acetic acid in mice, and skin irritation reactions were observed in rabbits. Carprofen groups and tolfenamic acid group could inhibit the mouse auriclate tumefaction induced by xylol, and inhibit the rats foot swelling induced by carrageenin. The anti - inflammatory effects of carprofen I group and toffenamie acid group were better than carprofen II group, the pain threshold of carprofen I group and tolfenamic acid group at 15 minutes and 30 minutes were prolonged in mice. The number of writhing times induced by acetic acid in mice was significantly reduced by all groups. The writhing inhibition percentages of carprofen I,carprofen II and tolfenamic acid group were 34.7%, 17.5% and 42.6% respectively. The time of first writhing response of tolfenamic acid group was prolonged. The skin irritation test＇ s results showed that there were no abnormal changes in rabbits. Carprofen I injection had rapid and exact anti -inflammatory and analgesic effection better than carprofen II injection. |
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| Keywords: | Meloxicam Tolfenamic Acid Anti-inflammatory Analgesia Skin irritation |
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