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| 三苯双脒肠溶片在羊体内药物代谢动力学试验 | |
| 引用本文： | 席耐,宋迎春,党新生,石保新,台凡力,严风.三苯双脒肠溶片在羊体内药物代谢动力学试验[J].中国兽医杂志,2011,47(7). |
| 作者姓名： | 席耐 宋迎春 党新生 石保新 台凡力 严风 |
| 作者单位： | 1. 新疆巴音郭楞蒙古自治州动物疾病控制与诊断中心,新疆 库尔勒,841000 2. 新疆巴音郭楞蒙古自治州林业局,新疆 库尔勒,841000 3. 新疆维吾尔自治区畜牧科学院兽医研究所,新疆 乌鲁木齐,830000 4. 中国农业科学院上海兽医研究所农业部寄生虫重点开放实验室,上海 闵行,200232 |
| 基金项目： | 新疆维吾尔自治区少数民族科技骨干人才特殊培养科研专项资金项目(2002-14) |
| 摘 要： | 为研究三苯双脒在绵羊体内动态变化的规律,采用方法如下:绵羊1次口服给药60、120、180 mg/kg体重3个剂量组,依据消除速率常数、吸收率常数、达峰时、血药浓度-时间曲线等主要药动学参数,经上海宏能软件有限公司开发的临床药物代谢动力学软件进行数据分析,符合血管外给药一级吸收一室模型,主要药动学参数为:吸收率常数Ka=0.15129h,t1/2Ka=4.74h,消除速率常数Ke=0.082 121h,t1/2Ke=8.46h,t1/2=19.03 h,达峰时tmax=8.0 h,Cmax=6257μg/L,血药浓度-时间曲线下面积AUC=300 51μg/L.h。三苯双脒肠溶片在羊体内吸收快、半衰期长等特点。说明三苯双脒肠溶片在药效试验剂量范围内比较安全。 |
| 关 键 词： | 三苯双脒 药物代谢动力学 绵羊 |
Research of pharmacokinetics for tribendimidine in sheep |
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| XI Nai,SONG Ying-chun,DANG Xin-sheng,SHI Bao-xin,TAI Fan-li,YAN Feng.Research of pharmacokinetics for tribendimidine in sheep[J].Chinese Journal of Veterinary Medicine,2011,47(7). | |
| Authors: | XI Nai SONG Ying-chun DANG Xin-sheng SHI Bao-xin TAI Fan-li YAN Feng |
| Institution: | XI Nai1,SONG Ying-chun1,DANG Xin-sheng2,SHI Bao-xin3,TAI Fan-li4,YAN Feng4(1.Control and Diagnose Centre in Animal's Disease of Mongolian Automonous Prefecture in Bayinguoleng of Xinjiang,Kuerle 841000,China,2.Forestry Bureau of Mongolian Automonous Prefecture in Bayinguoleng of Xinjiang,3.Veterinary Research Institute,Xinjiang Academy of Animal Science,Urumqi 830000,4.Shanghai Veterinary Research Institute,CAAS,The Key Open Laboratory for Animal Parasitology,Ministry of Agricultur... |
| Abstract: | To research the dynamic change of tribendimidine in sheep,Sheep were given three dosages(60 mg/kg,120 mg/kg,180 mg/kg),according to absorption rate constant(Ka),elimination rate constant(Ke),tmax,blood drug level timetable diaphragmatic surface(AUC) and other main pharmacokinetics parameter.Using clinic pharmacokinetics software to carry out data analysis by Shanghai Hongneng software limited company to develop.The results showed that it was consistent with outside blood vessel dosaged first order absorptio... |
| Keywords: | tribendimidine pharmacokinetic sheep |
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