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| 盐酸沃尼妙林肠溶微丸的研制 | |
| 引用本文： | 陈兴荣,方炳虎,刘晓莎,时书宁,刘小艳,陈良柱.盐酸沃尼妙林肠溶微丸的研制[J].中国兽医杂志,2011,47(7). |
| 作者姓名： | 陈兴荣 方炳虎 刘晓莎 时书宁 刘小艳 陈良柱 |
| 作者单位： | 1. 广东温氏食品集团有限公司,广东 新兴,527422 2. 华南农业大学兽医学院,广东 广州,510642 3. 广东海大集团股份有限公司,广东 广州,511400 4. 广东大华农动物保健品股份有限公司,广东 新兴,527400 |
| 基金项目： | 国家自然科学基金资助项目(30771628) |
| 摘 要： | 沃尼妙林是新一代截短侧耳素(pleuromutilin)类抗生素。试验以丙烯酸树脂水分散体为肠溶包衣材料,单因素与正交试验筛选处方及工艺条件,用流化床包衣技术及挤出-滚圆法制备10%盐酸沃尼妙林肠溶微丸。研制的肠溶微丸外观、含量和释放度在加速试验条件下均保持稳定;以75~150 g/t饲料混饲给药,10%盐酸沃尼妙林肠溶微丸对猪痢疾有良好治疗效果,明显优于痢菌净。研究表明,盐酸沃尼妙林肠溶微丸质量符合药学要求,具有良好的体外肠靶向性,可用于猪肠道疾病的防制。 |
| 关 键 词： | 盐酸沃尼妙林 肠溶微丸 挤出-滚圆法 药效学 |
Development of valnemulin hydrochloride enteric pellets |
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| CHEN Xing-rong,FANG Bing-hu,LIU Xiao-sha,SHI Shu-ning,LIU Xiao-yan,CHEN Liang-zhu.Development of valnemulin hydrochloride enteric pellets[J].Chinese Journal of Veterinary Medicine,2011,47(7). | |
| Authors: | CHEN Xing-rong FANG Bing-hu LIU Xiao-sha SHI Shu-ning LIU Xiao-yan CHEN Liang-zhu |
| Institution: | CHEN Xing-rong1,FANG Bing-hu2,LIU Xiao-sha3,SHI Shu-ning4,LIU Xiao-yan4,CHEN Liang-zhu4(1.Guangdong Wen's Food Group Co.Ltd,Xinxing 527422,China,2.College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,3.Guangdong Haid Group Co.Ltd,Guangzhou 511400,4.Guangdong Dahuanong Animal Health Products Co.Ltd,Xinxing 527400,China) |
| Abstract: | Valnemulin hydrochloride enteric pellets were developed by extrusion-spheronization and coated by fluid-bed with acrylic acid resin aqueous dispersion.The formulation and technology of valnemulin hydrochloride enteric pellets were selected by single-factor and orthogonal test.Its pharmacodynamics studies were also researched in this paper.The results showed that the coated pellets had smooth roundness,good reproductivity of inter-batch and good enteric-release property in vitro.In summary,the new productrat... |
| Keywords: | valnemulin hydrochloride enteric pellets extrusion-spheronization pharmacodynamic |
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