| 豫医无毛小鼠卵巢观察 |
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| 引用本文： | 朱奎成,章金涛,王纯耀,杜春燕,邢金山.豫医无毛小鼠卵巢观察[J].中国兽医学报,2011,31(7). |
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| 作者姓名： | 朱奎成 章金涛 王纯耀 杜春燕 邢金山 |
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| 作者单位： | 郑州大学实验动物中心,河南郑州,450052 |
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| 基金项目： | 国家自然科学基金资助项目(39970119); 河南省教育厅自然科学研究基金资助项目(2007310019) |
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| 摘 要： | 为了探讨无毛基因的突变对小鼠卵巢的影响，采用病理组织学和流式细胞术研究豫医无毛小鼠卵巢的形态学以及卵巢颗粒细胞周期和凋亡的变化。结果显示6月龄无毛小鼠卵巢颗粒细胞Ap峰和G0／G1期显著高于2月龄无毛小鼠和2、6月龄昆明小鼠。该研究表明，无毛基因的突变诱发了小鼠卵巢颗粒细胞的凋亡，雌性突变小鼠怀孕困难。
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| 关 键 词： | 无毛小鼠 卵巢 病理组织学 流式细胞术 |
Studies on the ovary of female YYHL mice |
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| ZHU Kui-cheng,ZHANG Jin-tao,WANG Chun-yao,DU Chun-yan,XING Jin-shan.Studies on the ovary of female YYHL mice[J].Chinese Journal of Veterinary Science,2011,31(7). |
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| Authors: | ZHU Kui-cheng ZHANG Jin-tao WANG Chun-yao DU Chun-yan XING Jin-shan |
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| Institution: | ZHU Kui-cheng,ZHANG Jin-tao,WANG Chun-yao,DU Chun-yan,XING Jin-shan(Laboratory Animal Center,Zhengzhou University,Zhengzhou 450052,China) |
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| Abstract: | To explore the effect of a mutation in the hr gene on ovaries of mouse.The study was designed to analyse the structure,apoptosis and cell cycle in YYHL mice by pathohistology and flow cytometry.The accumulation of cells in the G1 phase and a significant apoptosis were present in ovarian granulose cells of YYHL mice at 6 months compared with YYHL mice at 2 months and from 2 to 6 months of age in wide-type mice.The results showed that the apoptosis of ovarian granulose cells induced by hairless gene may reduc... |
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| Keywords: | hairless mice ovary pathohistology flow cytometry |
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