Fosfomycin susceptibility of canine methicillin-resistant Staphylococcus pseudintermedius isolates |
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| Authors: | Matthew DiCicco Scott Weese Suresh Neethirajan Joyce Rousseau Ameet Singh |
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| Institution: | 1. BioNano Laboratory, School of Engineering, University of Guelph, Guelph N1G 2W1, Canada;2. Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph N1G 2W1, Canada;3. Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph N1G 2W1, Canada |
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| Abstract: | The effectiveness of fosfomycin was examined across 31 methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains by agar dilution. Prevalence of the fosfomycin-resistance determinant gene, fosB, was assessed by PCR analysis. Results found that 84% of isolates were fosfomycin-susceptible. Interestingly, 87% of isolates possessed fosB, indicating no association between this putative staphylococci resistance gene and phenotypic resistance. Further evaluation of fosfomycin as a potential treatment of MRSP in dogs is warranted. |
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| Keywords: | Fosfomycin Methicillin-resistant Staphylococcus pseudintermedius MRSP fosB |
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