| 禽Ⅰ型副粘病毒各种禽源分离株的免疫原性 |
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| 引用本文： | 王林果,韦平,韦天超,李康然,黄淼章,黄钰缤,文艳玲,杨宗维.禽Ⅰ型副粘病毒各种禽源分离株的免疫原性[J].中国兽医学报,2007,27(6):790-794. |
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| 作者姓名： | 王林果 韦平 韦天超 李康然 黄淼章 黄钰缤 文艳玲 杨宗维 |
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| 作者单位： | 广西大学,养禽与禽病研究所,广西,南宁,530005 |
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| 基金项目： | 广西自然科学基金;广西玉林市科研项目 |
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| 摘 要： | 分别制备了源于鸡、鹅、鸽、鹌鹑、孔雀、画眉鸟、珍珠鸡的禽型副粘病毒(APMV-1)7个强毒分离毒株和商品弱毒疫苗株克隆30(C30)的灭活油乳剂苗,并用这8种灭活油乳剂苗和C30株的活疫苗分别在鸡、鹌鹑、鹅和鸽进行了免疫及交叉攻毒保护试验。免疫后(PI)分别测定试验禽血清的新城疫病毒(NDV)血凝抑制(HI)抗体的滴度,并于PI 5周用强毒株进行攻毒。结果表明,鸽的HI抗体几何平均滴度(MAT)为9.00~10.0 log2,鸡的为7.13~7.63 log2,鹌鹑的为5.00~5.13 log2,鹅对灭活油乳剂苗的为5.63~6.38 log2、而对C30株活疫苗的仅为3.38log2;除了C30株活疫苗免疫鹅提供的保护率比较低(20%)外,8种油乳剂苗都能对同源或者异源强毒株的攻毒提供比较高的保护率(66.75%~100%)。研究结果表明,经典疫苗株C30与近年来从各种不同禽类分离的致病性APMV-1野毒株之间、不同禽源分离株之间的抗原性,以及各种不同禽源分离株的之间的免疫原性差异均不大。
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| 关 键 词： | 禽Ⅰ型副粘病毒 免疫原性 抗原性 血凝抑制抗体滴度 免疫交叉保护试验 |
| 文章编号： | 1005-4545（2007）06-0790-05 |
| 修稿时间： | 2006-06-16 |
Immunogenicity of avian paramyxovirus type 1 isolates originated from different avian species |
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| WANG Lin-guo,WEI Ping,WEI Tian-chao,LI Kang-ran,HUANG Miao-zhang,HUANG Yu-bin,WEN Yan-ling,YANG Zong-wei.Immunogenicity of avian paramyxovirus type 1 isolates originated from different avian species[J].Chinese Journal of Veterinary Science,2007,27(6):790-794. |
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| Authors: | WANG Lin-guo WEI Ping WEI Tian-chao LI Kang-ran HUANG Miao-zhang HUANG Yu-bin WEN Yan-ling YANG Zong-wei |
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| Institution: | Institute for Poultry Science and Health ,Guangxi University,Nanning 530005 ,China |
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| Abstract: | The immunization and cross-protection test was preformed in chickens,quails,geese and pigeons by using the oil-emulsion vaccines(OEV) prepared from different APMV-1 isolates from chickens,geese,pigeons,quails,peacock,thrush,Guinea fowl,and commercial attenuated vaccine strain Clone30(C30),respectively and live C30.Sera of the birds were collected and detected for hemoagglutinization inhibit(HI) antibody against NDV at different weeks post-immunization(PI),and then all the birds were challenged with the virulent NDV at PI 5 weeks.The mean average titers(MAT) of HI antibody were 9.00-10.0 log2,7.13-7.63 log2,5.00-5.13 log2,5.63-6.38 log2(C30-OEV) and 3.38 log2(live-C30) in pigeons,chickens,geese and quails,respectively.HI titers of the group vaccinated with OEV were 5.63-6.38;All the eight OEV vaccines can provide good protections(66.75%-100%) against the challenges with homogenous and heterogeneous viruses,except that live C30 can only provide the protection of 20% in geese.The results of the study demonstrated that there is no much difference in antigenicity and immunogenicity between the classic vaccine strain C30 and recent isolates of APMV-1 or among the isolates. |
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| Keywords: | APMV-1 immunogenicity antigenicity HI antibody titer immunization and cross-protection test |
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