| ORN及其类似物的天然抗病毒活性与临床应用研究进展 |
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| 引用本文： | 何小兵,景志忠,贾怀杰,房永祥,陈国华,曾爽.ORN及其类似物的天然抗病毒活性与临床应用研究进展[J].动物医学进展,2012(3):80-84. |
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| 作者姓名： | 何小兵 景志忠 贾怀杰 房永祥 陈国华 曾爽 |
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| 作者单位： | 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室农业部兽医公共卫生重点实验室 |
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| 基金项目： | 国家自然科学基金项目(30871884);国家高新技术“863”项目(2011AA10A211) |
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| 摘 要： | 病毒来源的免疫刺激RNA寡聚核苷酸(ORN)及其类似物是一类重要的病原相关分子模式(PAMPs),通过TLR7/8激活机体的免疫系统释放一系列干扰素和炎性细胞因子,发挥天然抗病毒免疫。ORN及其类似物可作为免疫调节剂或疫苗佐剂预防和治疗病毒病、自身免疫病和肿瘤。论文就ORN及其类似物的天然抗病毒活性和临床应用等研究进展进行综述。
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| 关 键 词： | Toll样受体 免疫刺激RNA寡聚核苷酸 类似物 抗病毒活性 临床应用 |
Innate Antiviral Activity and Clinical Application of ORN and Its Analogs |
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| HE Xiao-bing,JING Zhi-zhong,JIA Huai-jie,FANF Yong-xiang,CHEN Guo-hua,ZENG Shuang.Innate Antiviral Activity and Clinical Application of ORN and Its Analogs[J].Progress In Veterinary Medicine,2012(3):80-84. |
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| Authors: | HE Xiao-bing JING Zhi-zhong JIA Huai-jie FANF Yong-xiang CHEN Guo-hua ZENG Shuang |
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| Institution: | (State Key Laboratory of Veterinary Etiological Biology,Key Laboratory of Veterinary Public Health of Ministry of Agriculture, Lanzhou Veterinary Research Institute,CAAS,Lanzhou,Gansu,730046,China) |
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| Abstract: | Immunostimulatory RNA oligoribonucleotides(ORN)-derived from ssRNA virus and its analogs act as PAMPs,are capable of rapidly initiating the innate antiviral immune response by TLR7/8 to assure host protection through induction of interferons and inflammatory cytokines.ORN and its analogs therefore may be exploited for immunomodulator or adjuvant against virus infection,cancer and autoimmune disease.Here,we highlight our current understanding of the innate antiviral activity and clinical application of ORN and its analogs. |
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| Keywords: | Toll-like receptors immunostimulatory RNA oligoribonucleotides analogs innate antiviral activity clinical application |
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