| 肠上皮细胞中内质网应激与动物肠道炎症机制的研究进展 |
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| 引用本文： | 文伟,陈凤鸣,黄兴国,李颖慧.肠上皮细胞中内质网应激与动物肠道炎症机制的研究进展[J].动物营养学报,2020(2):530-539. |
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| 作者姓名： | 文伟 陈凤鸣 黄兴国 李颖慧 |
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| 作者单位： | 湖南农业大学动物科学技术学院;湖南省畜禽安全生产协同创新中心 |
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| 基金项目： | 国家自然科学基金青年科学基金项目（31802074）;湖南省自然科学基金青年基金项目（2019JJ50264）;农业领域重点研发项目（2017NK2310) |
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| 摘 要： | 近年来,内质网应激参与动物炎症性肠病发病机制的研究引起了广泛关注,未折叠或错误折叠的蛋白质在内质网腔中过量积累而引发内质网应激,持续的内质网应激则会导致动物肠黏膜屏障损伤并诱发肠道炎症。本文就内质网应激发生机制、未折叠蛋白质反应及内质网应激与肠道炎症互作机制进行了综述,旨在为防治动物肠道炎症提出新的治疗策略。
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| 关 键 词： | 内质网应激 肠道炎症 未折叠蛋白质 肠上皮细胞 |
Research Progress of Endoplasmic Reticulum Stress and Intestinal Inflammation Mechanism in Intestinal Epithelial Cells |
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| WEN Wei,CHEN Fengming,HUANG Xingguo,LI Yinghui.Research Progress of Endoplasmic Reticulum Stress and Intestinal Inflammation Mechanism in Intestinal Epithelial Cells[J].Acta Zoonutrimenta Sinica,2020(2):530-539. |
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| Authors: | WEN Wei CHEN Fengming HUANG Xingguo LI Yinghui |
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| Institution: | (College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China;Hunan Co?Innovation Center of Animal Production Safety,Changsha 410128,China) |
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| Abstract: | In recent years,the study of endoplasmic reticulum stress involved in the pathogenesis of inflamma?tory bowel disease in animals has caused wide attention,unfolded or misfolded proteins accumulate in the lu?men of the endoplasmic reticulum and cause endoplasmic reticulum stress,persistent endoplasmic reticulum stress can lead to intestinal mucosal barrier damage and induce intestinal inflammation.This paper reviewed the endoplasmic reticulum stress relieving mechanism,unfolded protein response and interaction mechanism of en?doplasmic reticulum stress with intestinal inflammation,aimd to propose a new therapeutic strategy for preven?ting and curing intestinal inflammation in animals. |
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| Keywords: | endoplasmic reticulum stress intestinal inflammation unfolded protein intestinal epithelial cells |
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