| 氯代苯和烷基酚类化合物斑马鱼毒性的定量构效关系分析 |
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| 引用本文： | 李运彩,张松林,白芳铭,赵国庆,陈粉丽.氯代苯和烷基酚类化合物斑马鱼毒性的定量构效关系分析[J].南方水产,2010,6(3):19-23. |
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| 作者姓名： | 李运彩 张松林 白芳铭 赵国庆 陈粉丽 |
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| 作者单位： | 1. 西北师范大学地理与环境科学学院,甘肃,兰州,730070
2. 中国科学院研究生院,北京,100049 |
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| 基金项目： | 西北师范大学地理与环境科学学院2009年青年教师学术科研资金项目，甘肃省自然科学基金，甘肃省教育厅基金，甘肃省重点学科生态经济学和教育部"西部地区高等学校高级访问学者计划"基金 |
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| 摘 要： | 文章以ISO推荐使用的标准化鱼类毒性实验动物斑马鱼（Brachydaniorerio）为试验材料，选取10种典型氯代苯和烷基酚类化合物为研究对象进行了毒性试验。将斑马鱼毒性数据（-lgLC50）与受试物参数（2X^v、lgP）在SPSS13．0中进行回归分析，建立回归模型，可认为氯代苯毒性与2XV、烷基酚毒性与lgP之间均存在显著的线性关系，简要分析了其存在的不同致毒机理。
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| 关 键 词： | 氯代苯 烷基酚 斑马鱼 定量构效关系 |
QSAR analysis of toxicity of chloro-benzene and alkylphenolic compounds to zebrafish |
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| LI Yuncai,ZHANG Songlin,BAI Fangming,ZHAO Guoqing,CHEN Fenli.QSAR analysis of toxicity of chloro-benzene and alkylphenolic compounds to zebrafish[J].South China Fisheries Science,2010,6(3):19-23. |
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| Authors: | LI Yuncai ZHANG Songlin BAI Fangming ZHAO Guoqing CHEN Fenli |
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| Institution: | 1. College of Geography and Environmental Sciences, Northwest Normal University, Lanzhou 730070, China ; 2. Graduate University of Chinese Academy of Sciences, Beiijng 100049, China) |
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| Abstract: | In this paper, adult zebrafish （Brachydanio rerio） which was recommended by the ISO standardization for testing fish toxicity was exposed to 10 kinds of chloro-benzene and alkylphenolic compounds. Their toxic effects were assessed in the toxicity test. Through multi-stepwise regression in SPSS 13.0 with the toxicity data （ -lg LCso） and the molecular parameters （2xV, lg P）, two regression equations were obtained. The results showed that there was significant linear relation between cHore-benzene toxicity and 2Xv as well as al- kylphenol toxicity and lg P. Furthermore, their toxicity mechanisms were discussed briefly. |
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| Keywords: | chloro-benzene alkylphenol zebrafish（Brachydanio rerio） QSAR |
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