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Elimination half‐life of intravenously administered equine cardiac troponin I in healthy ponies |
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| Authors: | M S KRAUS B B KAUFER A DAMIANI N OSTERRIEDER M RISHNIW W SCHWARK A R GELZER T J DIVERS |
| Institution: | 1. Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, New York, USA;2. Institut für Virologie, Freie Universit?t Berlin, Berlin, Germany.;3. Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, New York, USA;4. Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, New York, USA |
| Abstract: | Reasons for performing study: To date, no information is available on the true biological elimination half‐life (T1/2) of cardiac troponin I (cTnI) in the equine species. Such data are required to better evaluate the optimal time to acquire the cTnI sample following acute myocardial injury. Objective: To determine the T1/2 of equine cTnI. Methods: Four healthy ponies received i.v. injections of recombinant equine cTnI. Plasma cTnI concentrations were measured with a point‐of‐care cTnI analyser at multiple time points after injection. Standard pharmacokinetic analysis was performed to establish the T1/2 of cTnI. Results: The average T1/2 of cTnI was determined to be 0.47 h using a single rate elimination model. Conclusion: The elimination of recombinant equine cTnI following i.v. administration is very rapid. Establishing the T1/2 of troponin provides critical information in understanding the clinical application of this cardiac biomarker in equine practice. |
| Keywords: | horse heart troponin |