| 降钙素基因相关肽对内皮素诱发大鼠心律失常作用的影响 |
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| 引用本文： | 肖向红,高静.降钙素基因相关肽对内皮素诱发大鼠心律失常作用的影响[J].野生动物,1995(2):31-32. |
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| 作者姓名： | 肖向红 高静 |
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| 作者单位： | 东北林业大学，黑龙江省医学情报研究所 |
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| 摘 要： | 本文采用成年ＳＤ大鼠经冠状动脉口注入内皮素ＥＴ，６００ｐｍｏｌ／ｋｇ）和降钙素基因相关肽（ＣＧＲＰ，１７０ｐｍｏｌ／ｋｇ），观察ＣＧＲＰ对ＥＴ引起大鼠心律失常作用的影响。发现ＥＴ可诱发心律失常的发生，ＣＧＲＰ对ＥＴ引起的心律失常具有协同作用。结果提示：作用方式可能是对心肌造成的缺血／再灌注损伤使细胞内钙超载和氧自由大量产生。
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| 关 键 词： | 内皮素 降钙素基因 肽 缺血 心律失常 大鼠 |
Effects Calcitonin Gene-Related Peptide(CGRP)on rats arrhythmias induced by Endothelin(ET) |
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| Authors: | Xiao Xianghorig |
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| Institution: | Northeast Forestry University |
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| Abstract: | The effects of CGRP on rats arrhymias were studied by injecting CGRP 170pmol/ kg into coronary arteries or rats after ET 600pmol/kg was injected.Observating the action of CGRP,it was found that CGRP had the joint effect on rats arrhythmias induced by ET.The result showed that the accounts for rats arrhythmias were not only myocardial ischemia-recerfusion injury,but also intra cellular calcium overload and large amount of oxygen free radical caused by CGRP and ET. |
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| Keywords: | Endothelin Calcitonin Gene-Related Peptide Myocardial Ischemia-Recerfusion Injury Arrhythmias |
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