Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta |
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| Authors: | T R Sutter K Guzman K M Dold W F Greenlee |
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| Institution: | Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709. |
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| Abstract: | Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), a widespread environmental contaminant, may elicit its effects by altering gene expression in susceptible cells. Five TCDD-responsive complementary DNA clones were isolated from a human keratinocyte cell line. One of these clones encodes plasminogen activator inhibitor-2, a factor that influences growth and differentiation by regulating proteolysis of the extracellular matrix. Another encodes the cytokine interleukin-1 beta. Thus, TCDD alters the expression of growth regulatory genes and has effects similar to those of other tumor-promoting agents that affect both inflammation and differentiation. |
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