| 牛基因组中新的microRNA预测及分析 |
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| 引用本文： | 穆松,钟金城,陈智华,徐利娟.牛基因组中新的microRNA预测及分析[J].中国草食动物,2010,30(1). |
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| 作者姓名： | 穆松 钟金城 陈智华 徐利娟 |
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| 作者单位： | 西南民族大学动物遗传育种学国家民委-教育部共建重点实验室,成都,610041 |
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| 摘 要： | MicroRNA(miRNA)是一类调控真核基因表达的非编码小分子RNA,目前已证实miRNA在生物体生长、发育和疾病发生等过程中起着重要的作用。用同源搜索的计算分析法预测新的miRNAs是当前发现和鉴定miRNA的有效方法之一,本研究根据NCBI数据库中的牛EST、GSS信息以及猪、家犬、人、大猩猩和小家鼠5种哺乳动物的已经注册miRNA分子信息,预测牛新的候选miRNA,通过碱基错配、二级结构、A+U含量、自由能大小等分析候选序列特征,得到了17条牛新的候选miRNA。这对进一步寻找牛的miRNA和遗传育种研究提供了新的思路,具有一定的理论和实际意义。
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| 关 键 词： | 牛 miRNA 预测 分析 |
Prediction and Analysis of Novel miRNA in Cattle |
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| Mu Song,Zhong Jin-cheng,Chen Zhi-hua,Xu Li-jun.Prediction and Analysis of Novel miRNA in Cattle[J].China Herbivores,2010,30(1). |
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| Authors: | Mu Song Zhong Jin-cheng Chen Zhi-hua Xu Li-jun |
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| Institution: | Key Laboratory of Animal Genetics and Breeding;State Ethnic Affairs Commission-Ministry of Education;Southwest University for Nationalities;Chengdu 610041 |
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| Abstract: | MicroRNAs(miRNAs) is a kind of non-coding small RNA which regulates the expression of gene in eukaryotic organism.MiRNA confirmed have played an important role in the organism growth,development and disease processed.Predicting new miRNAs by computer-based homology search analysis is an effective way to discover and identify miRNA.In this study,a new candidate bovine miRNA was predicted according to bovine EST,GSS information in NCBI database,as well as pigs,dogs,human,gorilla and Mus musculus miRNA informa... |
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| Keywords: | cattle miRNA prediction analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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